Polycomb Repressive Complex 2
"Polycomb Repressive Complex 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE COMPLEX 1 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063151
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| MeSH Number(s) |
D05.500.781.750 D08.811.913.555.500.800.400.500 D12.776.660.235.600.200 D12.776.664.235.800.200 D12.776.930.780.890.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 2".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 2".
This graph shows the total number of publications written about "Polycomb Repressive Complex 2" by people in this website by year, and whether "Polycomb Repressive Complex 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polycomb Repressive Complex 2" by people in Profiles.
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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. Nat Commun. 2021 12 21; 12(1):7349.
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Three additional patients with EED-associated overgrowth: potential mutation hotspots identified? J Hum Genet. 2019 Jun; 64(6):561-572.
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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood. 2015 Feb 26; 125(9):1367-76.
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A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. FASEB J. 2014 Jul; 28(7):3183-96.
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MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24.
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Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Res. 2012 Sep 15; 72(18):4672-81.
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Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes. Mol Oncol. 2012 Oct; 6(5):494-506.
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TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One. 2010 Aug 30; 5(8):e12479.
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Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn. 2010 Jul; 239(7):2024-33.
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The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1112-7.