"Filamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
| Descriptor ID |
D064448
|
| MeSH Number(s) |
A11.284.430.214.190.750.050.414 D05.750.078.730.315 D12.776.210.249 D12.776.220.525.315
|
| Concept/Terms |
Filamin B- Filamin B
- beta-Filamin
- beta Filamin
- beta-Filamins
- Filamin 1-Like Protein
- 1-Like Protein, Filamin
- 1-Like Proteins, Filamin
- Filamin 1 Like Protein
- Filamin 1-Like Proteins
- Protein, Filamin 1-Like
- Proteins, Filamin 1-Like
Filamin A- Filamin A
- Filamin 1
- alpha-Filamin
- alpha Filamin
- alpha-Filamins
- 280 kDa Actin-Binding Protein
- 280 kDa Actin Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Filamins".
Below are MeSH descriptors whose meaning is more specific than "Filamins".
This graph shows the total number of publications written about "Filamins" by people in this website by year, and whether "Filamins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Filamins" by people in Profiles.
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Phenotypic Expression, Natural History, and Risk Stratification of Cardiomyopathy Caused by Filamin C Truncating Variants. Circulation. 2021 11 16; 144(20):1600-1611.
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FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2020 04; 57(4):254-257.
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Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development. Anat Rec (Hoboken). 2019 01; 302(1):117-124.
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New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277.
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Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation. Biochim Biophys Acta. 2014 Feb; 1843(2):234-44.
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Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves. J Mol Cell Cardiol. 2013 Jul; 60:50-9.
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Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19.
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Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis. Dev Dyn. 2010 Jul; 239(7):2118-27.