"TRPC6 Cation Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
| Descriptor ID |
D000074287
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| MeSH Number(s) |
D12.776.157.530.400.150.850 D12.776.157.530.400.901.500.500 D12.776.543.550.450.150.900 D12.776.543.585.400.150.850 D12.776.543.585.400.901.500.500
|
| Concept/Terms |
TRPC6 Cation Channel- TRPC6 Cation Channel
- Cation Channel, TRPC6
- Channel, TRPC6 Cation
- Transient Receptor Potential Cation Channel Subfamily C, Member 6
- TRPC6
|
Below are MeSH descriptors whose meaning is more general than "TRPC6 Cation Channel".
Below are MeSH descriptors whose meaning is more specific than "TRPC6 Cation Channel".
This graph shows the total number of publications written about "TRPC6 Cation Channel" by people in this website by year, and whether "TRPC6 Cation Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "TRPC6 Cation Channel" by people in Profiles.
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A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. J Am Soc Nephrol. 2018 07; 29(7):1917-1927.
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The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 03 22; 7(1):299.
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TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F393-7.
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Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli. Kidney Int. 2014 Sep; 86(3):506-14.