Methylenetetrahydrofolate Reductase (NADPH2)

"Methylenetetrahydrofolate Reductase (NADPH2)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.

Descriptor ID	D042965
MeSH Number(s)	D08.811.682.662.290 D12.776.331.775
Concept/Terms	Methylenetetrahydrofolate Reductase (NADPH2) Methylenetetrahydrofolate Reductase (NADPH2) Methylenetetrahydrofolate Reductase (NADPH) Methylene-THF Reductase (NADPH) Methylenetetrahydrofolate Reductase 5,10-Methylenetetrahydrofolate Reductase (NADPH) Methylene Tetrahydrofolate Reductase Tetrahydrofolate Reductase, Methylene

Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Reductase (NADPH2)".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxidoreductases Acting on CH-NH Group Donors [D08.811.682.662]
Methylenetetrahydrofolate Reductase (NADPH2) [D08.811.682.662.290]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Flavoproteins [D12.776.331]
Methylenetetrahydrofolate Reductase (NADPH2) [D12.776.331.775]

Below are MeSH descriptors whose meaning is related to "Methylenetetrahydrofolate Reductase (NADPH2)".

Below are MeSH descriptors whose meaning is more specific than "Methylenetetrahydrofolate Reductase (NADPH2)".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methylenetetrahydrofolate Reductase (NADPH2)" by people in this website by year, and whether "Methylenetetrahydrofolate Reductase (NADPH2)" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2008 and 2009 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2000	0	1	1
2008	1	1	2
2009	2	0	2
2010	1	0	1
2011	0	2	2
2013	1	0	1
2017	1	0	1

Below are the most recent publications written about "Methylenetetrahydrofolate Reductase (NADPH2)" by people in Profiles.

Hewett KM, Lorenzetti B, Jackson BF. Ataxia and Headache in a Child: A Case of Acute Cerebellar Infarction. Pediatr Emerg Care. 2017 Aug; 33(8):570-572.

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Figueiredo JC, Levine AJ, Crott JW, Baurley J, Haile RW. Folate-genetics and colorectal neoplasia: what we know and need to know next. Mol Nutr Food Res. 2013 Apr; 57(4):607-27.

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Muwakkit SA, Majdalani M, Hourani R, Mahfouz RA, Otrock ZK, Bilalian C, Chan AK, Abboud M, Mikati MA. Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatr Neurol. 2011 Sep; 45(3):155-8.

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Levine AJ, Lee W, Figueiredo JC, Conti DV, Vandenberg DJ, Davis BD, Edlund CK, Henning SM, Heber D, Stern MC, Haile RW. Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study. Cancer Causes Control. 2011 Apr; 22(4):541-52.

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Levine AJ, Figueiredo JC, Lee W, Poynter JN, Conti D, Duggan DJ, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Marchand L, Baron JA, Limburg PJ, Ulrich CM, Haile RW. Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. Cancer Epidemiol Biomarkers Prev. 2010 Jan; 19(1):89-100.

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Muwakkit SA, Saab R, Sanjad SA, Bhar SI, Ishak RS, Samad ZA, Chan AK, Abboud MR. Renal venous thrombosis in a newborn with prothrombotic risk factors. Blood Coagul Fibrinolysis. 2009 Sep; 20(6):458-60.

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Peddareddygari LR, Dutra AV, Levenstien MA, Sen S, Grewal RP. An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. BMC Neurol. 2009 Jul 22; 9:37.

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Levine AJ, Wallace K, Tsang S, Haile RW, Saibil F, Ahnen D, Cole BF, Barry EL, Munroe DJ, Ali IU, Ueland P, Baron JA. MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. Cancer Epidemiol Biomarkers Prev. 2008 Sep; 17(9):2409-15.

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Figueiredo JC, Levine AJ, Grau MV, Midttun O, Ueland PM, Ahnen DJ, Barry EL, Tsang S, Munroe D, Ali I, Haile RW, Sandler RS, Baron JA. Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2136-45.

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Biousse V, Kerrison JB, Newman NJ. Is non-arteritic anterior ischaemic optic neuropathy related to homocysteine? Br J Ophthalmol. 2000 May; 84(5):555.

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