Colorectal Neoplasms, Hereditary Nonpolyposis
"Colorectal Neoplasms, Hereditary Nonpolyposis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
| Descriptor ID |
D003123
|
| MeSH Number(s) |
C04.588.274.476.411.307.190 C04.700.250 C06.301.371.411.307.190 C06.405.249.411.307.190 C06.405.469.158.356.190 C06.405.469.491.307.190 C16.320.700.250 C18.452.284.255
|
| Concept/Terms |
Hereditary Nonpolyposis Colorectal Cancer- Hereditary Nonpolyposis Colorectal Cancer
- Colorectal Cancer Hereditary Nonpolyposis
- Lynch Syndrome I
- Lynch Cancer Family Syndrome I
- Lynch Syndrome
- Syndrome, Lynch
- Colon Cancer, Familial Nonpolyposis
- Hereditary Nonpolyposis Colon Cancer
|
Below are MeSH descriptors whose meaning is more general than "Colorectal Neoplasms, Hereditary Nonpolyposis".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Site [C04.588]
- Digestive System Neoplasms [C04.588.274]
- Gastrointestinal Neoplasms [C04.588.274.476]
- Intestinal Neoplasms [C04.588.274.476.411]
- Colorectal Neoplasms [C04.588.274.476.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.588.274.476.411.307.190]
- Neoplastic Syndromes, Hereditary [C04.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.700.250]
- Digestive System Diseases [C06]
- Digestive System Neoplasms [C06.301]
- Gastrointestinal Neoplasms [C06.301.371]
- Intestinal Neoplasms [C06.301.371.411]
- Colorectal Neoplasms [C06.301.371.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.301.371.411.307.190]
- Gastrointestinal Diseases [C06.405]
- Gastrointestinal Neoplasms [C06.405.249]
- Intestinal Neoplasms [C06.405.249.411]
- Colorectal Neoplasms [C06.405.249.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.249.411.307.190]
- Intestinal Diseases [C06.405.469]
- Colonic Diseases [C06.405.469.158]
- Colorectal Neoplasms [C06.405.469.158.356]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.158.356.190]
- Intestinal Neoplasms [C06.405.469.491]
- Colorectal Neoplasms [C06.405.469.491.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.491.307.190]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Neoplastic Syndromes, Hereditary [C16.320.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C16.320.700.250]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- DNA Repair-Deficiency Disorders [C18.452.284]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C18.452.284.255]
Below are MeSH descriptors whose meaning is more specific than "Colorectal Neoplasms, Hereditary Nonpolyposis".
This graph shows the total number of publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in this website by year, and whether "Colorectal Neoplasms, Hereditary Nonpolyposis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 6 | 0 | 6 |
| 2012 | 4 | 0 | 4 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 5 | 0 | 5 |
| 2016 | 3 | 0 | 3 |
| 2018 | 3 | 0 | 3 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Profiles.
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Management of gliomas in patients with Lynch syndrome. Neuro Oncol. 2021 01 30; 23(1):167-168.
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Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Genet Med. 2021 04; 23(4):705-712.
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Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome. Br J Cancer. 2019 11; 121(10):869-876.
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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med. 2020 01; 22(1):15-25.
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Cancer Risks for PMS2-Associated Lynch Syndrome. J Clin Oncol. 2018 10 10; 36(29):2961-2968.
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Physical activity and the risk of colorectal cancer in Lynch syndrome. Int J Cancer. 2018 11 01; 143(9):2250-2260.
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Worldwide Practice Patterns in Lynch Syndrome Diagnosis and?Management, Based on Data From the International Mismatch Repair Consortium. Clin Gastroenterol Hepatol. 2018 12; 16(12):1901-1910.e11.
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Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2017 03; 26(3):366-375.
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Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome. Int J Epidemiol. 2016 06; 45(3):940-53.
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Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort. BMJ Open. 2016 Feb 19; 6(2):e010293.