"Mecamylamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Below are MeSH descriptors whose meaning is more general than "Mecamylamine".
Below are MeSH descriptors whose meaning is more specific than "Mecamylamine".
This graph shows the total number of publications written about "Mecamylamine" by people in this website by year, and whether "Mecamylamine" was a major or minor topic of these publications.
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|Year||Major Topic||Minor Topic||Total|
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Below are the most recent publications written about "Mecamylamine" by people in Profiles.
Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine. Behav Brain Res. 2014 Apr 01; 262:42-6.
Validation of a high-throughput, automated electrophysiology platform for the screening of nicotinic agonists and antagonists. J Biomol Screen. 2013 Jan; 18(1):116-27.
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS One. 2011; 6(12):e28790.
Differential pharmacologies of mecamylamine enantiomers: positive allosteric modulation and noncompetitive inhibition. J Pharmacol Exp Ther. 2009 Feb; 328(2):525-32.
Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells. Life Sci. 2004 Mar 12; 74(17):2111-28.
Changes in sleep after acute and repeated administration of nicotine in the rat. Psychopharmacology (Berl). 1999 Jul; 145(2):133-8.
The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior. Brain Res. 1988 Feb 16; 441(1-2):209-14.
Effect of end-diastolic volume on the canine left ventricular ejection fraction. Am Heart J. 1985 May; 109(5 Pt 1):1059-69.