Hydroxymethylglutaryl CoA Reductases
"Hydroxymethylglutaryl CoA Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
| Descriptor ID |
D006903
|
| MeSH Number(s) |
D08.811.682.047.820.150.415
|
| Concept/Terms |
Hydroxymethylglutaryl CoA Reductases- Hydroxymethylglutaryl CoA Reductases
- Hydroxymethylglutaryl CoA Reductase
- HMG CoA Reductases
- 3-Hydroxy-3-methylglutaryl CoA Reductase
- 3 Hydroxy 3 methylglutaryl CoA Reductase
- CoA Reductase, 3-Hydroxy-3-methylglutaryl
- Reductase, 3-Hydroxy-3-methylglutaryl CoA
- HMG CoA Reductase
|
Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl CoA Reductases".
Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl CoA Reductases".
This graph shows the total number of publications written about "Hydroxymethylglutaryl CoA Reductases" by people in this website by year, and whether "Hydroxymethylglutaryl CoA Reductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1995 | 3 | 0 | 3 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydroxymethylglutaryl CoA Reductases" by people in Profiles.
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Paintlia AS, Paintlia MK, Singh AK, Singh I. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008 May; 73(5):1381-93.
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Arikan MC, Shapiro SD, Mariani TJ. Induction of macrophage elastase (MMP-12) gene expression by statins. J Cell Physiol. 2005 Jul; 204(1):139-45.
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Buechler RD, Peffley DM. Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. Mol Carcinog. 2004 Sep; 41(1):39-53.
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Peffley DM, Gayen AK. Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J Nutr. 2003 Jan; 133(1):38-44.
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Hentosh P, Yuh SH, Elson CE, Peffley DM. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells. Mol Carcinog. 2001 Nov; 32(3):154-66.
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Elson CE, Peffley DM, Hentosh P, Mo H. Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. Proc Soc Exp Biol Med. 1999 Sep; 221(4):294-311.
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Peffley DM, Gayen AK, Morand OH. Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin. Biochem Pharmacol. 1998 Aug 15; 56(4):439-49.
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Peffley DM, Gayen AK. Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. Arch Biochem Biophys. 1997 Jan 15; 337(2):251-60.
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Gayen AK, Peffley DM. The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. Arch Biochem Biophys. 1995 Oct 01; 322(2):475-85.
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Peffley DM, Gayen AK. Mevalonate regulates polysome distribution and blocks translation-dependent suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA: relationship to translational control. Somat Cell Mol Genet. 1995 May; 21(3):189-204.