Eukaryotic Initiation Factor-4E
"Eukaryotic Initiation Factor-4E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.
| Descriptor ID |
D039561
|
| MeSH Number(s) |
D12.776.157.725.750.374 D12.776.835.725.868.500.750
|
| Concept/Terms |
Eukaryotic Initiation Factor-4E- Eukaryotic Initiation Factor-4E
- Eukaryotic Initiation Factor 4E
- Factor-4E, Eukaryotic Initiation
- Initiation Factor-4E, Eukaryotic
- Peptide Initiation Factor EIF-4E
- Peptide Initiation Factor EIF 4E
- EIF4E
- Eukaryotic Peptide Initiation Factor-4E
- Eukaryotic Peptide Initiation Factor 4E
- CDC33 Gene Product
- EIF-4E
- EIF 4E
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4E".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4E".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4E" by people in this website by year, and whether "Eukaryotic Initiation Factor-4E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Eukaryotic Initiation Factor-4E" by people in Profiles.
-
Inhibition of the MNK1/2-eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer. Mol Cancer Ther. 2023 02 01; 22(2):192-204.
-
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 02 19; 16(2):334-343.
-
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. Exp Cell Res. 2013 Aug 01; 319(13):2103-2112.
-
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol. 2008 May 15; 75(10):1981-93.
-
Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. Arch Biochem Biophys. 2007 Sep 01; 465(1):266-73.
-
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67.
-
Regulation of c-jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase-1 (MNK1). FASEB J. 2006 Oct; 20(12):2133-5.
-
Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. J Mol Biol. 2006 Mar 03; 356(4):982-92.
-
The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat Struct Mol Biol. 2004 Jun; 11(6):503-11.
-
Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA. Biochem J. 2004 Feb 15; 378(Pt 1):73-82.