Mice, Inbred MRL lpr

"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.

Descriptor ID	D019463
MeSH Number(s)	B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555
Concept/Terms	Mice, Inbred MRL lpr Mice, Inbred MRL lpr Mouse, MRL lpr MRL lpr Mouse Mice, MRL lpr MRL lpr Mice Mouse, Inbred MRL lpr

Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".

Organisms [B]
Eukaryota [B01]
Animals [B01.050]
Animal Population Groups [B01.050.050]
Animals, Laboratory [B01.050.050.199]
Animals, Inbred Strains [B01.050.050.199.520]
Mice, Inbred Strains [B01.050.050.199.520.520]
Mice, Inbred MRL lpr [B01.050.050.199.520.520.555]
Chordata [B01.050.150]
Vertebrates [B01.050.150.900]
Mammals [B01.050.150.900.649]
Eutheria [B01.050.150.900.649.313]
Rodentia [B01.050.150.900.649.313.992]
Muridae [B01.050.150.900.649.313.992.635]
Murinae [B01.050.150.900.649.313.992.635.505]
Mice [B01.050.150.900.649.313.992.635.505.500]
Mice, Inbred Strains [B01.050.150.900.649.313.992.635.505.500.400]
Mice, Inbred MRL lpr [B01.050.150.900.649.313.992.635.505.500.400.555]

Below are MeSH descriptors whose meaning is related to "Mice, Inbred MRL lpr".

Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.

Bar chart showing 74 publications over 24 distinct years, with a maximum of 6 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	5	5
1998	0	2	2
1999	0	4	4
2000	1	5	6
2001	0	3	3
2002	2	2	4
2003	0	5	5
2004	0	5	5
2005	0	1	1
2006	1	3	4
2007	0	4	4
2008	0	4	4
2009	0	2	2
2010	0	2	2
2011	0	2	2
2012	0	5	5
2013	0	4	4
2014	0	4	4
2015	0	1	1
2017	0	1	1
2020	0	1	1
2021	0	1	1
2022	0	2	2

Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.

Ning W, Cheng D, Howe PH, Bian C, Kamen DL, Luo Z, Fu X, Ogunrinde E, Yang L, Wang X, Li QZ, Oates J, Zhang W, White D, Wan Z, Gilkeson GS, Jiang W. Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus. J Autoimmun. 2022 07; 131:102860.

View in: PubMed
Gudi R, Roy S, Sun W, Vasu C. Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus-prone mouse models. Immunology. 2022 04; 165(4):497-507.

View in: PubMed
Sundararaj K, Rodgers J, Angel P, Wolf B, Nowling TK. The role of neuraminidase in TLR4-MAPK signalling and the release of cytokines by lupus serum-stimulated mesangial cells. Immunology. 2021 04; 162(4):418-433.

View in: PubMed
Nowling TK, Rodgers J, Thiyagarajan T, Wolf B, Bruner E, Sundararaj K, Molano I, Gilkeson G. Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice. PLoS One. 2020; 15(3):e0230499.

View in: PubMed
Sundararaj K, Rodgers JI, Marimuthu S, Siskind LJ, Bruner E, Nowling TK. Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F630-F642.

View in: PubMed
Sundararaj KP, Thiyagarajan T, Molano I, Basher F, Powers TW, Drake RR, Nowling TK. FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. J Immunol. 2015 Dec 15; 195(12):5551-60.

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Sato S, Lennard Richard M, Brandon D, Jones Buie JN, Oates JC, Gilkeson GS, Zhang XK. A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression. Arthritis Rheumatol. 2014 Dec; 66(12):3436-44.

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Collins E, Gu F, Qi M, Molano I, Ruiz P, Sun L, Gilkeson GS. Differential efficacy of human mesenchymal stem cells based on source of origin. J Immunol. 2014 Nov 01; 193(9):4381-90.

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Nowling TK, Mather AR, Thiyagarajan T, Hernández-Corbacho MJ, Powers TW, Jones EE, Snider AJ, Oates JC, Drake RR, Siskind LJ. Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis. J Am Soc Nephrol. 2015 Jun; 26(6):1402-13.

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Bruschi M, Sinico RA, Moroni G, Pratesi F, Migliorini P, Galetti M, Murtas C, Tincani A, Madaio M, Radice A, Franceschini F, Trezzi B, Bianchi L, Giallongo A, Gatti R, Tardanico R, Scaloni A, D'Ambrosio C, Carnevali ML, Messa P, Ravani P, Barbano G, Bianco B, Bonanni A, Scolari F, Martini A, Candiano G, Allegri L, Ghiggeri GM. Glomerular autoimmune multicomponents of human lupus nephritis in vivo: a-enolase and annexin AI. J Am Soc Nephrol. 2014 Nov; 25(11):2483-98.

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