"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
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| MeSH Number(s) |
B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555
|
| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mouse, MRL lpr
- MRL lpr Mouse
- Mice, MRL lpr
- MRL lpr Mice
- Mouse, Inbred MRL lpr
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 5 | 5 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 4 | 4 |
| 2000 | 1 | 5 | 6 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 2 | 3 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 5 | 5 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus. J Autoimmun. 2022 07; 131:102860.
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Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus-prone mouse models. Immunology. 2022 04; 165(4):497-507.
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The role of neuraminidase in TLR4-MAPK signalling and the release of cytokines by lupus serum-stimulated mesangial cells. Immunology. 2021 04; 162(4):418-433.
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Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice. PLoS One. 2020; 15(3):e0230499.
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Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F630-F642.
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FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. J Immunol. 2015 Dec 15; 195(12):5551-60.
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A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression. Arthritis Rheumatol. 2014 Dec; 66(12):3436-44.
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Differential efficacy of human mesenchymal stem cells based on source of origin. J Immunol. 2014 Nov 01; 193(9):4381-90.
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Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis. J Am Soc Nephrol. 2015 Jun; 26(6):1402-13.
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Glomerular autoimmune multicomponents of human lupus nephritis in vivo: a-enolase and annexin AI. J Am Soc Nephrol. 2014 Nov; 25(11):2483-98.