Psychosine

"Psychosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An intermediate in the biosynthesis of cerebrosides. It is formed by reaction of sphingosine with UDP-galactose and then itself reacts with fatty acid-Coenzyme A to form the cerebroside.

Descriptor ID	D011609
MeSH Number(s)	D02.033.100.700.700 D02.092.063.700.700 D09.400.410.420.806 D10.390.470.806 D10.570.877.360.806
Concept/Terms	Psychosine Psychosine Sphingosine Galactoside Galactoside, Sphingosine Galactosylsphingosine

Below are MeSH descriptors whose meaning is more general than "Psychosine".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Alcohols [D02.033]
Amino Alcohols [D02.033.100]
Sphingosine [D02.033.100.700]
Psychosine [D02.033.100.700.700]
Amines [D02.092]
Amino Alcohols [D02.092.063]
Sphingosine [D02.092.063.700]
Psychosine [D02.092.063.700.700]
Carbohydrates [D09]
Glycoconjugates [D09.400]
Glycolipids [D09.400.410]
Glycosphingolipids [D09.400.410.420]
Psychosine [D09.400.410.420.806]
Lipids [D10]
Glycolipids [D10.390]
Glycosphingolipids [D10.390.470]
Psychosine [D10.390.470.806]
Membrane Lipids [D10.570]
Sphingolipids [D10.570.877]
Glycosphingolipids [D10.570.877.360]
Psychosine [D10.570.877.360.806]

Below are MeSH descriptors whose meaning is related to "Psychosine".

Below are MeSH descriptors whose meaning is more specific than "Psychosine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Psychosine" by people in this website by year, and whether "Psychosine" was a major or minor topic of these publications.

Bar chart showing 18 publications over 11 distinct years, with a maximum of 2 publications in 2002 and 2006 and 2008 and 2010 and 2013 and 2015 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	0	2
2003	1	0	1
2005	1	0	1
2006	2	0	2
2007	0	1	1
2008	2	0	2
2010	1	1	2
2013	2	0	2
2014	0	1	1
2015	0	2	2
2016	0	2	2

Below are the most recent publications written about "Psychosine" by people in Profiles.

Won JS, Singh AK, Singh I. Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease. J Neurosci Res. 2016 11; 94(11):990-1006.

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Dai M, Liou B, Swope B, Wang X, Zhang W, Inskeep V, Grabowski GA, Sun Y, Pan D. Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease. PLoS One. 2016; 11(9):e0162367.

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Dasgupta N, Xu YH, Li R, Peng Y, Pandey MK, Tinch SL, Liou B, Inskeep V, Zhang W, Setchell KD, Keddache M, Grabowski GA, Sun Y. Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. Hum Mol Genet. 2015 Dec 15; 24(24):7031-48.

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Sun Y, Florer J, Mayhew CN, Jia Z, Zhao Z, Xu K, Ran H, Liou B, Zhang W, Setchell KD, Gu J, Grabowski GA. Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology. PLoS One. 2015; 10(3):e0118771.

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Burrow TA, Sun Y, Prada CE, Bailey L, Zhang W, Brewer A, Wu SW, Setchell KDR, Witte D, Cohen MB, Grabowski GA. CNS, lung, and lymph node involvement in Gaucher disease type 3 after 11 years of therapy: clinical, histopathologic, and biochemical findings. Mol Genet Metab. 2015 Feb; 114(2):233-241.

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Sun Y, Zhang W, Xu YH, Quinn B, Dasgupta N, Liou B, Setchell KD, Grabowski GA. Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease. PLoS One. 2013; 8(3):e57560.

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Won JS, Kim J, Paintlia MK, Singh I, Singh AK. Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease. Brain Res. 2013 May 01; 1508:44-52.

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Contreras MA, Ries WL, Shanmugarajan S, Arboleda G, Singh I, Singh AK. Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):601-8.

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Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15; 19(6):1088-97.

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Contreras MA, Haq E, Uto T, Singh I, Singh AK. Psychosine-induced alterations in peroxisomes of twitcher mouse liver. Arch Biochem Biophys. 2008 Sep 15; 477(2):211-8.

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