"Carbolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
| Descriptor ID |
D002243
|
| MeSH Number(s) |
D03.383.725.150 D03.633.100.473.155 D03.633.300.154
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Carbolines".
Below are MeSH descriptors whose meaning is more specific than "Carbolines".
This graph shows the total number of publications written about "Carbolines" by people in this website by year, and whether "Carbolines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Carbolines" by people in Profiles.
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Effects of MAO inhibition and a combination of minor alkaloids, ?-carbolines, and acetaldehyde on nicotine self-administration in adult male rats. Drug Alcohol Depend. 2015 Oct 01; 155:243-52.
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CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development. J Org Chem. 2012 Mar 02; 77(5):2299-309.
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Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142. Pharmacol Biochem Behav. 2011 Sep; 99(3):408-13.
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Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety. Bioorg Med Chem. 2009 Nov 15; 17(22):7775-82.
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Kinetic studies and bioactivity of potential manzamine prodrugs. J Nat Prod. 2008 Jul; 71(7):1218-21.
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2-N-Methyl modifications and SAR studies of manzamine A. Bioorg Med Chem. 2008 Jul 15; 16(14):6702-6.
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Successful use of phosphodiesterase type 5 inhibitors to control symptomatic esophageal hypercontractility: a case report. Dig Dis Sci. 2005 Nov; 50(11):2059-62.
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Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. J Nat Prod. 2004 Aug; 67(8):1314-8.
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New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases. J Med Chem. 2004 Jul 01; 47(14):3512-7.
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New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod. 2003 Jun; 66(6):823-8.