bcl-2-Associated X Protein

"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.

Descriptor ID	D051028
MeSH Number(s)	D12.644.360.075.718.400 D12.776.476.075.718.400
Concept/Terms	bcl-2-Associated X Protein bcl-2-Associated X Protein Protein, bcl-2-Associated X X Protein, bcl-2-Associated bcl 2 Associated X Protein Bax Apoptosis Regulator Protein Bax Protein bcl2-Associated X Protein bcl2 Associated X Protein bcl2-Associated X Protein Isoform beta bcl2-Associated X Protein Isoform beta bcl2 Associated X Protein Isoform beta Bax-beta Protein Bax beta Protein bcl2-Associated X Protein Isoform sigma bcl2-Associated X Protein Isoform sigma bcl2 Associated X Protein Isoform sigma Bax-sigma Protein Bax sigma Protein bcl2-Associated X Protein Isoform omega bcl2-Associated X Protein Isoform omega bcl2 Associated X Protein Isoform omega Bax-omega Protein Bax omega Protein bcl2-Associated X Protein Isoform alpha bcl2-Associated X Protein Isoform alpha bcl2 Associated X Protein Isoform alpha Bax-alpha Protein Bax alpha Protein bcl2-Associated X Protein Isoform delta bcl2-Associated X Protein Isoform delta bcl2 Associated X Protein Isoform delta Bax-delta Protein Bax delta Protein

Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Proto-Oncogene Proteins c-bcl-2 [D12.644.360.075.718]
bcl-2-Associated X Protein [D12.644.360.075.718.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Proto-Oncogene Proteins c-bcl-2 [D12.776.476.075.718]
bcl-2-Associated X Protein [D12.776.476.075.718.400]

Below are MeSH descriptors whose meaning is related to "bcl-2-Associated X Protein".

Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in this website by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.

Bar chart showing 62 publications over 19 distinct years, with a maximum of 7 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	3	3
2000	0	4	4
2001	0	2	2
2002	0	4	4
2003	0	5	5
2004	0	2	2
2005	0	5	5
2006	0	1	1
2007	2	5	7
2008	1	4	5
2009	1	3	4
2010	0	5	5
2011	0	3	3
2012	1	0	1
2013	0	3	3
2014	0	2	2
2017	0	1	1
2019	0	2	2
2020	0	3	3

Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles.

Khathayer F, Ray SK. Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines. Neurochem Res. 2020 Oct; 45(10):2336-2351.

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Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. J Pharmacol Exp Ther. 2020 08; 374(2):308-318.

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Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355.

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Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145.

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Taylor MA, Khathayer F, Ray SK. Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochem Res. 2019 Jul; 44(7):1715-1725.

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Skala E, Kowalczyk T, Toma M, Szemraj J, Radek M, Pytel D, Wieczfinska J, Wysokinska H, Sliwinski T, Sitarek P. Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract. Mol Cell Biochem. 2018 Aug; 445(1-2):89-97.

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Song H, Wu F, Zhang Y, Zhang Y, Wang F, Jiang M, Wang Z, Zhang M, Li S, Yang L, Wang XL, Cui T, Tang D. Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis. PLoS One. 2014; 9(10):e110273.

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Ureshino RP, Hsu YT, do Carmo LG, Yokomizo CH, Nantes IL, Smaili SS. Inhibition of cytoplasmic p53 differentially modulates Ca(2+) signaling and cellular viability in young and aged striata. Exp Gerontol. 2014 Oct; 58:120-7.

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Talwar S, House R, Sundaramurthy S, Balasubramanian S, Yu H, Palanisamy V. Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR. J Biol Chem. 2014 Feb 07; 289(6):3487-500.

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Zhang S, Wang Y, Chen Z, Kim S, Iqbal S, Chi A, Ritenour C, Wang YA, Kucuk O, Wu D. Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells. Prostate. 2013 Nov; 73(15):1681-9.

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