"Calpain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
| Descriptor ID |
D002154
|
| MeSH Number(s) |
D08.811.277.656.262.500.120 D08.811.277.656.300.200.120
|
| Concept/Terms |
Calpain- Calpain
- Calcium-Activated Protease
- Calcium Activated Protease
- Protease, Calcium-Activated
- Calcium-Dependent Neutral Proteinase
- Calcium Dependent Neutral Proteinase
- Neutral Proteinase, Calcium-Dependent
- Proteinase, Calcium-Dependent Neutral
- Calcium-Dependent Neutral Protease
- Calcium Dependent Neutral Protease
- Neutral Protease, Calcium-Dependent
- Protease, Calcium-Dependent Neutral
- Desminase
- Ca2+-Activated Protease
- Ca2+ Activated Protease
- Protease, Ca2+-Activated
- Calcium-Activated Neutral Proteinase
- Calcium Activated Neutral Proteinase
- Neutral Proteinase, Calcium-Activated
- Proteinase, Calcium-Activated Neutral
- Calcium-Activated Neutral Protease
- Calcium Activated Neutral Protease
- Neutral Protease, Calcium-Activated
- Protease, Calcium-Activated Neutral
|
Below are MeSH descriptors whose meaning is more general than "Calpain".
Below are MeSH descriptors whose meaning is more specific than "Calpain".
This graph shows the total number of publications written about "Calpain" by people in this website by year, and whether "Calpain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 1 | 4 |
| 1996 | 2 | 0 | 2 |
| 1997 | 4 | 0 | 4 |
| 1998 | 3 | 0 | 3 |
| 1999 | 3 | 1 | 4 |
| 2000 | 4 | 1 | 5 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 4 | 1 | 5 |
| 2004 | 6 | 2 | 8 |
| 2005 | 3 | 1 | 4 |
| 2006 | 4 | 0 | 4 |
| 2007 | 5 | 3 | 8 |
| 2008 | 6 | 3 | 9 |
| 2009 | 4 | 3 | 7 |
| 2010 | 2 | 6 | 8 |
| 2011 | 1 | 4 | 5 |
| 2012 | 3 | 1 | 4 |
| 2013 | 2 | 2 | 4 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 4 | 5 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Calpain" by people in Profiles.
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Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. Int J Mol Sci. 2022 Nov 10; 23(22).
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Calpain activation and progression of inflammatory cycles in Parkinson's disease. Front Biosci (Landmark Ed). 2022 01 13; 27(1):20.
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Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021 02 17; 13(581).
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Cell-Permeable Calpain Inhibitor SJA6017 Provides Functional Protection to Spinal Motoneurons Exposed to MPP. Neurotox Res. 2020 Oct; 38(3):640-649.
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Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease. Exp Neurol. 2020 08; 330:113315.
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Cytokine/chemokine dysregulation in progressive MS patient is apparent and can be modulated by calpain inhibition. Metab Brain Dis. 2020 02; 35(2):255-261.
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Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease. Prog Mol Biol Transl Sci. 2019; 167:107-124.
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Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells. J Cell Biochem. 2019 04; 120(4):6264-6276.
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Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity. BMC Neurosci. 2018 08 13; 19(1):50.
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Neuron-microglia interaction induced bi-directional cytotoxicity associated with calpain activation. J Neurochem. 2016 11; 139(3):440-455.