Anti-Glomerular Basement Membrane Disease
"Anti-Glomerular Basement Membrane Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
| Descriptor ID |
D019867
|
| MeSH Number(s) |
C08.381.483.156 C12.777.419.570.363.304 C13.351.968.419.570.363.304 C20.111.190
|
| Concept/Terms |
Anti-Glomerular Basement Membrane Disease- Anti-Glomerular Basement Membrane Disease
- Anti Glomerular Basement Membrane Disease
- Anti-GBM Disease
- Anti GBM Disease
- Lung Purpura with Nephritis
- Goodpasture's Syndrome
- Goodpastures Syndrome
- Syndrome, Goodpasture's
- Goodpasture Syndrome
- Syndrome, Goodpasture
|
Below are MeSH descriptors whose meaning is more general than "Anti-Glomerular Basement Membrane Disease".
Below are MeSH descriptors whose meaning is more specific than "Anti-Glomerular Basement Membrane Disease".
This graph shows the total number of publications written about "Anti-Glomerular Basement Membrane Disease" by people in this website by year, and whether "Anti-Glomerular Basement Membrane Disease" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Anti-Glomerular Basement Membrane Disease" by people in Profiles.
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Human anti-a3(IV)NC1 antibody drug conjugates target glomeruli to resolve nephritis. Am J Physiol Renal Physiol. 2015 Oct 15; 309(8):F680-4.
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Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol. 2015 Jun 15; 194(12):5713-24.
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65-year-old woman with shortness of breath and dark urine. Mayo Clin Proc. 2011 Sep; 86(9):912-5.
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Modeling of human anti-GBM antibody-alpha3(IV)NC1 interactions predicts antigenic cross-linking through contact of both heavy chains with repeating epitopes on alpha3(IV)NC1. Am J Nephrol. 2009; 30(5):474-80.
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Goodpasture's 1919 article on the etiology of influenza-the historical road to what we now call Goodpasture Syndrome. Am J Med Sci. 2009 Aug; 338(2):154.
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Anemia, cough, and acute renal failure in a teenager: case presentation and review. Fetal Pediatr Pathol. 2007 May-Jun; 26(3):119-24.
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Renal transplant in patients with Alport's syndrome. Am J Kidney Dis. 2002 Apr; 39(4):769-75.
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High affinity of anti-GBM antibodies from Goodpasture and transplanted Alport patients to alpha3(IV)NC1 collagen. Kidney Int. 2000 Jul; 58(1):115-22.
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Human Goodpasture anti-alpha3(IV)NC1 autoantibodies share structural determinants. Kidney Int. 1998 Feb; 53(2):402-7.
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Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. J Am Soc Nephrol. 1997 Nov; 8(11):1795-800.