Glutamate-Cysteine Ligase
"Glutamate-Cysteine Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
| Descriptor ID |
D005721
|
| MeSH Number(s) |
D08.811.464.259.850.400
|
| Concept/Terms |
Glutamate-Cysteine Ligase- Glutamate-Cysteine Ligase
- Glutamate Cysteine Ligase
- Ligase, Glutamate-Cysteine
- gamma-Glutamyl-Cysteine Synthetase
- Synthetase, gamma-Glutamyl-Cysteine
- gamma Glutamyl Cysteine Synthetase
- Glutamylcysteine Synthetase
- Synthetase, Glutamylcysteine
|
Below are MeSH descriptors whose meaning is more general than "Glutamate-Cysteine Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Cysteine Ligase".
This graph shows the total number of publications written about "Glutamate-Cysteine Ligase" by people in this website by year, and whether "Glutamate-Cysteine Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 2 | 1 | 3 |
| 2000 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate-Cysteine Ligase" by people in Profiles.
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Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice. Exp Neurol. 2018 04; 302:129-135.
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Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes. Mol Cell Proteomics. 2016 Feb; 15(2):493-505.
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Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System. J Biol Chem. 2015 Nov 13; 290(46):27829-40.
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The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug; 294(2):480-7.
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Coordinate changes in expression of protective genes in drug-resistant cells. Chem Biol Interact. 1998 Apr 24; 111-112:199-211.
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Co-ordinated over-expression of the MRP and gamma-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines. Int J Cancer. 1998 Mar 02; 75(5):757-61.
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Lack of correlation of MRP and gamma-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen-transformed human mesothelial cells. Cancer Chemother Pharmacol. 1998; 42(6):441-6.
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Importance of glutathione and associated enzymes in drug response. Oncol Res. 1997; 9(6-7):295-302.
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Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. J Clin Invest. 1996 Sep 01; 98(5):1210-7.
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Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program. Mol Pharmacol. 1996 Jul; 50(1):149-59.