"Intercalating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
| Descriptor ID |
D007364
|
| MeSH Number(s) |
D27.720.470.410.360
|
| Concept/Terms |
Intercalating Agents- Intercalating Agents
- Agents, Intercalating
- Intercalating Ligands
- Ligands, Intercalating
- Intercalators
- Intercalative Compounds
- Compounds, Intercalative
|
Below are MeSH descriptors whose meaning is more general than "Intercalating Agents".
Below are MeSH descriptors whose meaning is more specific than "Intercalating Agents".
This graph shows the total number of publications written about "Intercalating Agents" by people in this website by year, and whether "Intercalating Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Intercalating Agents" by people in Profiles.
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Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate. Chem Commun (Camb). 2013 Jun 28; 49(51):5796-8.
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Natural product DNA major groove binders. Nat Prod Rep. 2012 Feb; 29(2):134-43.
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Probing the recognition surface of a DNA triplex: binding studies with intercalator-neomycin conjugates. Biochemistry. 2010 Jul 06; 49(26):5540-52.
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Triple recognition of B-DNA. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):4974-9.
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4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria. J Med Chem. 2008 Jun 26; 51(12):3466-79.
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Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4142-5.
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Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. J Am Chem Soc. 2003 Jul 09; 125(27):8070-1.