Mitral Valve Prolapse

"Mitral Valve Prolapse" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.

Descriptor ID	D008945
MeSH Number(s)	C14.280.484.400.500
Concept/Terms	Mitral Valve Prolapse Mitral Valve Prolapse Mitral Valve Prolapses Prolapse, Mitral Valve Prolapses, Mitral Valve Valve Prolapse, Mitral Valve Prolapses, Mitral Floppy Mitral Valve Floppy Mitral Valves Mitral Valve, Floppy Mitral Valves, Floppy Mitral Click-Murmur Syndrome Click-Murmur Syndrome, Mitral Mitral Click Murmur Syndrome Syndrome, Mitral Click-Murmur Systolic Click-Murmur Syndrome Click-Murmur Syndrome, Systolic Syndrome, Systolic Click-Murmur Systolic Click Murmur Syndrome Prolapsed Mitral Valve Mitral Valve, Prolapsed Mitral Valves, Prolapsed Prolapsed Mitral Valves Valve, Prolapsed Mitral Valves, Prolapsed Mitral Click-Murmur Syndrome Click Murmur Syndrome Click-Murmur Syndromes Syndrome, Click-Murmur Syndromes, Click-Murmur Mitral Valve Prolapse Syndrome

Below are MeSH descriptors whose meaning is more general than "Mitral Valve Prolapse".

Diseases [C]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Heart Valve Diseases [C14.280.484]
Heart Valve Prolapse [C14.280.484.400]
Mitral Valve Prolapse [C14.280.484.400.500]

Below are MeSH descriptors whose meaning is related to "Mitral Valve Prolapse".

Below are MeSH descriptors whose meaning is more specific than "Mitral Valve Prolapse".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitral Valve Prolapse" by people in this website by year, and whether "Mitral Valve Prolapse" was a major or minor topic of these publications.

Bar chart showing 16 publications over 9 distinct years, with a maximum of 5 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2010	0	1	1
2012	1	0	1
2015	2	0	2
2018	1	0	1
2019	3	0	3
2020	0	1	1
2021	5	0	5
2022	1	0	1

Below are the most recent publications written about "Mitral Valve Prolapse" by people in Profiles.

Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 05 01; 43(17):1668-1680.

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Morningstar JE, Gensemer C, Moore R, Fulmer D, Beck TC, Wang C, Moore K, Guo L, Sieg F, Nagata Y, Bertrand P, Spampinato RA, Glover J, Poelzing S, Gourdie RG, Watts K, Richardson WJ, Levine RA, Borger MA, Norris RA. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. J Am Heart Assoc. 2021 12 21; 10(24):e022332.

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Yu M, Kyryachenko S, Debette S, Amouyel P, Schott JJ, Le Tourneau T, Dina C, Norris RA, Hagège AA, Jeunemaitre X, Bouatia-Naji N. Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse. Circ Genom Precis Med. 2021 10; 14(5):e003148.

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Morningstar JE, Nieman A, Wang C, Beck T, Harvey A, Norris RA. Mitral Valve Prolapse and Its Motley Crew-Syndromic Prevalence, Pathophysiology, and Progression of a Common Heart Condition. J Am Heart Assoc. 2021 07 06; 10(13):e020919.

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Guo L, Beck T, Fulmer D, Ramos-Ortiz S, Glover J, Wang C, Moore K, Gensemer C, Morningstar J, Moore R, Schott JJ, Le Tourneau T, Koren N, Norris RA. DZIP1 regulates mammalian cardiac valve development through a Cby1-ß-catenin mechanism. Dev Dyn. 2021 10; 250(10):1432-1449.

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Kyryachenko S, Georges A, Yu M, Barrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras KK, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N. Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 03 05; 128(5):e84-e101.

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Fulmer D, Toomer KA, Glover J, Guo L, Moore K, Moore R, Stairley R, Gensemer C, Abrol S, Rumph MK, Emetu F, Lipschutz JH, McDowell C, Bian J, Wang C, Beck T, Wessels A, Renault MA, Norris RA. Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin. Dev Biol. 2020 07 01; 463(1):26-38.

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Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 05 22; 11(493).

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Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J, Ellinor PT, Levine RA, Slaugenhaupt SA, Hagège AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 05; 12(5):e002497.

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Neri T, Hiriart E, van Vliet PP, Faure E, Norris RA, Farhat B, Jagla B, Lefrancois J, Sugi Y, Moore-Morris T, Zaffran S, Faustino RS, Zambon AC, Desvignes JP, Salgado D, Levine RA, de la Pompa JL, Terzic A, Evans SM, Markwald R, Pucéat M. Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis. Nat Commun. 2019 04 26; 10(1):1929.

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