"Leukocyte Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
| Descriptor ID |
D019272
|
| MeSH Number(s) |
D08.811.277.656.300.760.560.500 D08.811.277.656.959.350.560.500
|
| Concept/Terms |
Leukocyte Elastase- Leukocyte Elastase
- Elastase, Leukocyte
- Polymorphonuclear Leukocyte Elastase
- Elastase, Polymorphonuclear Leukocyte
- Leukocyte Elastase, Polymorphonuclear
- Neutrophil Elastase
- Elastase, Neutrophil
- PMN Elastase
- Elastase, PMN
- Granulocyte Elastase
- Elastase, Granulocyte
- Lysosomal Elastase
- Elastase, Lysosomal
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Elastase".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Elastase".
This graph shows the total number of publications written about "Leukocyte Elastase" by people in this website by year, and whether "Leukocyte Elastase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 |
| 2003 | 2 | 0 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Leukocyte Elastase" by people in Profiles.
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Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases. Int J Mol Sci. 2021 Oct 15; 22(20).
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The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study. Diab Vasc Dis Res. 2021 Jul-Aug; 18(4):14791641211032547.
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TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. Am J Physiol Lung Cell Mol Physiol. 2018 12 01; 315(6):L1003-L1014.
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Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosis. J Cyst Fibros. 2016 Mar; 15(2):227-33.
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SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. Anticancer Res. 2012 Sep; 32(9):3923-8.
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Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid. Matrix Biol. 2012 Jan; 31(1):38-44.
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Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010 Feb; 16(2):219-23.
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Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):53-60.
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To live and die in the LA (lung airway): mode of neutrophil death and progression of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):129-30.
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Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol. 2007 Jan; 170(1):65-74.