"Leukocyte Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
| Descriptor ID |
D019272
|
| MeSH Number(s) |
D08.811.277.656.300.760.560.500 D08.811.277.656.959.350.560.500
|
| Concept/Terms |
Leukocyte Elastase- Leukocyte Elastase
- Elastase, Leukocyte
- Polymorphonuclear Leukocyte Elastase
- Elastase, Polymorphonuclear Leukocyte
- Leukocyte Elastase, Polymorphonuclear
- Neutrophil Elastase
- Elastase, Neutrophil
- PMN Elastase
- Elastase, PMN
- Granulocyte Elastase
- Elastase, Granulocyte
- Lysosomal Elastase
- Elastase, Lysosomal
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Elastase".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Elastase".
This graph shows the total number of publications written about "Leukocyte Elastase" by people in this website by year, and whether "Leukocyte Elastase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 |
| 2003 | 2 | 0 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Leukocyte Elastase" by people in Profiles.
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Chu X, Sun Z, Baek DS, Li W, Mellors JW, Shapiro SD, Dimitrov DS. Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases. Int J Mol Sci. 2021 Oct 15; 22(20).
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Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro S, Overall CM, Johnson SR. TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. Am J Physiol Lung Cell Mol Physiol. 2018 12 01; 315(6):L1003-L1014.
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Gaggar A, Chen J, Chmiel JF, Dorkin HL, Flume PA, Griffin R, Nichols D, Donaldson SH. Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosis. J Cyst Fibros. 2016 Mar; 15(2):227-33.
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Enewold L, Mechanic LE, Bowman ED, Platz EA, Alberg AJ. SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. Anticancer Res. 2012 Sep; 32(9):3923-8.
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Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010 Feb; 16(2):219-23.
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Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):53-60.
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Minematsu N, Shapiro SD. To live and die in the LA (lung airway): mode of neutrophil death and progression of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):129-30.
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Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CT. Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering. Immunity. 2005 Jun; 22(6):679-91.
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Mahadeva R, Atkinson C, Li Z, Stewart S, Janciauskiene S, Kelley DG, Parmar J, Pitman R, Shapiro SD, Lomas DA. Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol. 2005 Feb; 166(2):377-86.
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Swystun V, Chen L, Factor P, Siroky B, Bell PD, Matalon S. Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L820-30.