"Aphidicolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
- Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
Below are MeSH descriptors whose meaning is more general than "Aphidicolin".
Below are MeSH descriptors whose meaning is more specific than "Aphidicolin".
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Below are the most recent publications written about "Aphidicolin" by people in Profiles.
Cell cycle-and proteasome-dependent formation of etoposide-induced replication protein A (RPA) or Mre11/Rad50/Nbs1 (MRN) complex repair foci. Cell Cycle. 2007 Oct 01; 6(19):2399-407.
Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res. 2000 Sep 15; 60(18):5027-30.
A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat Cell Mol Genet. 1999 Jan; 25(1):9-26.
Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma. Genomics. 1994 Jul 15; 22(2):319-26.
Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain. J Virol. 1993 Jul; 67(7):4323-36.
Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity. J Virol. 1991 Feb; 65(2):869-79.
Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes. Cancer Genet Cytogenet. 1988 Mar; 31(1):69-73.
Loss of common 3p14 fragile site expression in renal cell carcinoma with deletion breakpoint at 3p14. Cancer Genet Cytogenet. 1988 Mar; 31(1):75-82.