Cyclin-Dependent Kinase 8
"Cyclin-Dependent Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
| Descriptor ID |
D056850
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| MeSH Number(s) |
D05.500.374.500 D08.811.913.696.620.682.700.646.500.968 D12.644.360.024.309.500 D12.644.360.250.547 D12.776.157.057.072.500 D12.776.167.200.548 D12.776.476.024.388.500 D12.776.476.250.548 D12.776.660.551.500
|
| Concept/Terms |
Cyclin-Dependent Kinase 8- Cyclin-Dependent Kinase 8
- Cyclin Dependent Kinase 8
- Cdk8 Cyclin-Dependent Kinase
- Cdk8 Cyclin Dependent Kinase
- Cyclin-Dependent Kinase, Cdk8
- Kinase, Cdk8 Cyclin-Dependent
- Cdk8 Protein Kinase
- Kinase, Cdk8 Protein
- Protein Kinase, Cdk8
- Cell Division Protein Kinase 8
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 8".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 8" by people in this website by year, and whether "Cyclin-Dependent Kinase 8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 3 | 0 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 8" by people in Profiles.
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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in?vitro and in?vivo. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2201073119.
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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
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The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs. Cells. 2021 01 12; 10(1).
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Genome Editing As an Approach to the Study of in Vivo Transcription Reprogramming. Dokl Biochem Biophys. 2020 Jan; 490(1):43-46.
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Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 2019 11 09; 8(11).
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Characterizing CDK8/19 Inhibitors through a NF?B-Dependent Cell-Based Assay. Cells. 2019 10 06; 8(10).
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Identifying Cancers Impacted by CDK8/19. Cells. 2019 08 03; 8(8).
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CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 12 01; 78(23):6594-6606.
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Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene. 2018 08; 37(35):4792-4808.
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CDK8/19 Mediator kinases potentiate induction of transcription by NF?B. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10208-10213.