Inhibitory Concentration 50
"Inhibitory Concentration 50" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
| Descriptor ID |
D020128
|
| MeSH Number(s) |
E05.940.350 G07.690.936.563
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Inhibitory Concentration 50".
Below are MeSH descriptors whose meaning is more specific than "Inhibitory Concentration 50".
This graph shows the total number of publications written about "Inhibitory Concentration 50" by people in this website by year, and whether "Inhibitory Concentration 50" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 6 | 6 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 5 | 5 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 2 | 2 |
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 3 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 3 | 3 |
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Below are the most recent publications written about "Inhibitory Concentration 50" by people in Profiles.
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Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase. Bioorg Chem. 2021 07; 112:104925.
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404.
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The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs. Cells. 2021 01 12; 10(1).
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Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA. Clin Cancer Res. 2021 01 01; 27(1):226-236.
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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9.
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The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. J Dermatol Sci. 2018 Jun; 90(3):343-356.
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Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. Phytomedicine. 2018 Feb 01; 40:27-36.
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Eukaryotic Ribosomal Expansion Segments as Antimicrobial Targets. Biochemistry. 2017 10 10; 56(40):5288-5299.
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Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. J Med Chem. 2017 06 22; 60(12):4904-4922.
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Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B. J Nat Prod. 2016 10 28; 79(10):2538-2544.