"Kainic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
| Descriptor ID |
D007608
|
| MeSH Number(s) |
D03.383.773.400
|
| Concept/Terms |
Kainic Acid- Kainic Acid
- Acid, Kainic
- Digenic Acid
- Acid, Digenic
|
Below are MeSH descriptors whose meaning is more general than "Kainic Acid".
Below are MeSH descriptors whose meaning is more specific than "Kainic Acid".
This graph shows the total number of publications written about "Kainic Acid" by people in this website by year, and whether "Kainic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 2 | 3 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 1 | 3 |
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Below are the most recent publications written about "Kainic Acid" by people in Profiles.
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Smothers CT, Szumlinski KK, Worley PF, Woodward JJ. Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse. 2016 Jan; 70(1):33-9.
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Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec; 15(23-24):4051-63.
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Neely BA, Ferrante JA, Chaves JM, Soper JL, Almeida JS, Arthur JM, Gulland FM, Janech MG. Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PLoS One. 2014; 10(4):e0123295.
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Fisher JL. The neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunit. Neuropharmacology. 2014 Oct; 85:9-17.
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Smith KL, John CS, Sypek EI, Ongür D, Cohen BM, Barry SM, Bechtholt AJ. Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. Alcohol Clin Exp Res. 2014 May; 38(5):1307-14.
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Funk JA, Janech MG, Dillon JC, Bissler JJ, Siroky BJ, Bell PD. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol. 2014 Jun; 25(6):1187-97.
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Lowry ER, Kruyer A, Norris EH, Cederroth CR, Strickland S. The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration. Neuroscience. 2013 Apr 03; 235:215-25.
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Glavan G, See RE, Živin M. Differential patterns of synaptotagmin7 mRNA expression in rats with kainate- and pilocarpine-induced seizures. PLoS One. 2012; 7(5):e36114.
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Das A, McDowell M, O'Dell CM, Busch ME, Smith JA, Ray SK, Banik NL. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochem Res. 2010 Dec; 35(12):2175-83.
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Mulholland PJ, Carpenter-Hyland EP, Woodward JJ, Chandler LJ. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol. 2009 Feb; 43(1):45-50.