DNA-Directed DNA Polymerase
"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
| Descriptor ID |
D004259
|
| MeSH Number(s) |
D08.811.913.696.445.308.300
|
| Concept/Terms |
DNA-Directed DNA Polymerase- DNA-Directed DNA Polymerase
- DNA Directed DNA Polymerase
- DNA Polymerase, DNA-Directed
- Polymerase, DNA-Directed DNA
- DNA-Dependent DNA Polymerases
- DNA Dependent DNA Polymerases
- DNA Polymerases, DNA-Dependent
- Polymerases, DNA-Dependent DNA
- DNA Polymerases
- Polymerases, DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1994 | 2 | 0 | 2 |
| 1997 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2005 | 3 | 0 | 3 |
| 2006 | 3 | 0 | 3 |
| 2008 | 1 | 0 | 1 |
| 2009 | 3 | 0 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 3 | 0 | 3 |
| 2015 | 2 | 0 | 2 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.
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Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, McVey M. Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair. PLoS Genet. 2017 May; 13(5):e1006813.
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Czarnecki MW, Traktman P. The vaccinia virus DNA polymerase and its processivity factor. Virus Res. 2017 04 15; 234:193-206.
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Rahn JJ, Bestman JE, Stackley KD, Chan SS. Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth. Nucleic Acids Res. 2015 Dec 02; 43(21):10338-52.
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Beagan K, McVey M. Linking DNA polymerase theta structure and function in health and disease. Cell Mol Life Sci. 2016 Feb; 73(3):603-15.
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Zhang L, Chan SS, Wolff DJ. Mitochondrial disorders of DNA polymerase ? dysfunction: from anatomic to molecular pathology diagnosis. Arch Pathol Lab Med. 2011 Jul; 135(7):925-34.
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Hentosh P, Benjamin T, Hall L, Leap S, Loescher J, Poyner E, Sundin T, Whittle M, Wilkinson S, Peffley DM. Xeroderma pigmentosum variant: complementary molecular approaches to detect a 13 base pair deletion in the DNA polymerase eta gene. Exp Mol Pathol. 2011 Oct; 91(2):528-33.
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Boyle KA, Stanitsa ES, Greseth MD, Lindgren JK, Traktman P. Evaluation of the role of the vaccinia virus uracil DNA glycosylase and A20 proteins as intrinsic components of the DNA polymerase holoenzyme. J Biol Chem. 2011 Jul 15; 286(28):24702-13.
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Klein BJ, Bose D, Baker KJ, Yusoff ZM, Zhang X, Murakami KS. RNA polymerase and transcription elongation factor Spt4/5 complex structure. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):546-50.
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Chan SS, Naviaux RK, Basinger AA, Casas KA, Copeland WC. De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion. 2009 Sep; 9(5):340-5.
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Kasiviswanathan R, Longley MJ, Chan SS, Copeland WC. Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. J Biol Chem. 2009 Jul 17; 284(29):19501-10.