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    • Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
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Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.

Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan; 124(1):448-60.

View in: PubMed

subject areas
  • Angiotensin II
  • Angiotensin II Type 1 Receptor Blockers
  • Animals
  • Aorta
  • Aortic Aneurysm
  • Cells, Cultured
  • Disease Progression
  • Female
  • Haploinsufficiency
  • Humans
  • Loeys-Dietz Syndrome
  • Losartan
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation, Missense
  • Myocytes, Smooth Muscle
  • Phenotype
  • Receptors, Transforming Growth Factor beta
  • Signal Transduction
  • Smad2 Protein
  • Transforming Growth Factor beta

authors with profiles
  • Daniel P Judge
  • Russell A Norris