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Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
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Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan; 124(1):448-60.
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PubMed
subject areas
Angiotensin II
Angiotensin II Type 1 Receptor Blockers
Animals
Aorta
Aortic Aneurysm
Cells, Cultured
Disease Progression
Female
Haploinsufficiency
Humans
Loeys-Dietz Syndrome
Losartan
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Transgenic
Mutation, Missense
Myocytes, Smooth Muscle
Phenotype
Receptors, Transforming Growth Factor beta
Signal Transduction
Smad2 Protein
Transforming Growth Factor beta
authors with profiles
Daniel P Judge
Russell A Norris