Janet L. Fisher

TitleASSOC PROFESSOR-USC
InstitutionUniversity of South Carolina School of Medicine
DepartmentMDC PHARM/PHYS & NEURO
AddressMEDICAL V.A. #1
Columbia, South Carolina 29209
Phone(803)216-3506
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cadeddu R, Knutson DE, Mosher LJ, Loizou S, Odeh K, Fisher JL, Cook JM, Bortolato M. The a6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome. Biomolecules. 2021 01 28; 11(2). PMID: 33525455.
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    2. Lopes JE, Fisher JL, Flick HL, Wang C, Sun L, Ernstoff MS, Alvarez JC, Losey HC. ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 04; 8(1). PMID: 32317293.
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    3. Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Roni MSR, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA. Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung". Mol Pharm. 2019 Nov 04; 16(11):4756. PMID: 31633359.
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    4. Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Markovic BD, Banasr M, Cook JM, Savic M, Sibille E. Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Mol Neuropsychiatry. 2019 Apr; 5(2):84-97. PMID: 31192221.
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    5. Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA. A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung. Mol Pharm. 2018 05 07; 15(5):1766-1777. PMID: 29578347.
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    6. Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive Effects of a Novel a2/a3-Subtype Selective GABAA Receptor Positive Allosteric Modulator. ACS Chem Neurosci. 2017 06 21; 8(6):1305-1312. PMID: 28150939.
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    7. Fisher JL. The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors. Neuropharmacology. 2015 Dec; 99:471-80. PMID: 26277340.
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    8. Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Neuro Oncol. 2015 Jun; 17(6):801-9. PMID: 25618892.
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    9. Fisher JL. The neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunit. Neuropharmacology. 2014 Oct; 85:9-17. PMID: 24859608.
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    10. Jenkins MH, Steinberg SM, Alexander MP, Fisher JL, Ernstoff MS, Turk MJ, Mullins DW, Brinckerhoff CE. Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032. Pigment Cell Melanoma Res. 2014 May; 27(3):495-501. PMID: 24460976.
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    11. Mott DD, Grosenbaugh DK, Fisher JL. Polytherapy with stiripentol: consider more than just metabolic interactions. Epilepsy Behav. 2013 Dec; 29(3):585. PMID: 24094845.
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    12. Fisher JL, Housley PR. Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors. Cell Mol Neurobiol. 2013 Nov; 33(8):1099-108. PMID: 23975096.
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    13. Heidelberg LS, Warren JW, Fisher JL. SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat a3, a5, or a6 subunit subtypes coexpressed with ß3 and ?2 subunits. J Pharmacol Exp Ther. 2013 Oct; 347(1):235-41. PMID: 23902941.
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    14. Fisher JL, Mott DD. Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1. J Physiol. 2013 Oct 01; 591(19):4711-24. PMID: 23798491.
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    15. Schwarzer A, Wolf B, Fisher JL, Schwaab T, Olek S, Baron U, Tomlinson CR, Seigne JD, Crosby NA, Gui J, Hampton TH, Fadul CE, Heaney JA, Ernstoff MS. Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy. PLoS One. 2012; 7(10):e46600. PMID: 23118856.
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    16. Fisher JL, Mott DD. The auxiliary subunits Neto1 and Neto2 reduce voltage-dependent inhibition of recombinant kainate receptors. J Neurosci. 2012 Sep 12; 32(37):12928-33. PMID: 22973017.
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    17. Alexeev M, Grosenbaugh DK, Mott DD, Fisher JL. The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors. Neuropharmacology. 2012 Jun; 62(8):2507-14. PMID: 22445602.
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    18. Fisher JL, Mott DD. Distinct functional roles of subunits within the heteromeric kainate receptor. J Neurosci. 2011 Nov 23; 31(47):17113-22. PMID: 22114280.
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    19. Leahy JT, Chu-Shore CJ, Fisher JL. Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome. Neuropsychiatr Dis Treat. 2011; 7:673-81. PMID: 22128252.
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    20. Bianchi MT, Clark AG, Fisher JL. The wake-promoting transmitter histamine preferentially enhances a-4 subunit-containing GABAA receptors. Neuropharmacology. 2011 Sep; 61(4):747-52. PMID: 21640733.
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    21. Fisher JL. The effects of stiripentol on GABA(A) receptors. Epilepsia. 2011 Apr; 52 Suppl 2:76-8. PMID: 21463286.
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    22. Lee CY, Perez FM, Wang W, Guan X, Zhao X, Fisher JL, Guan Y, Sweitzer SM, Raja SN, Tao YX. Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury. Eur J Pain. 2011 Aug; 15(7):669-75. PMID: 21310637.
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    23. Fisher JL. Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines. Eur J Pharmacol. 2011 Mar 05; 654(2):160-5. PMID: 21237147.
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    24. Fisher MT, Fisher JL. Activation of alpha6-containing GABAA receptors by pentobarbital occurs through a different mechanism than activation by GABA. Neurosci Lett. 2010 Mar 08; 471(3):195-9. PMID: 20109529.
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    25. Mott DD, Rojas A, Fisher JL, Dingledine RJ, Benveniste M. Subunit-specific desensitization of heteromeric kainate receptors. J Physiol. 2010 Feb 15; 588(Pt 4):683-700. PMID: 20026616.
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    26. Nimmich ML, Heidelberg LS, Fisher JL. RNA editing of the GABA(A) receptor alpha3 subunit alters the functional properties of recombinant receptors. Neurosci Res. 2009 Apr; 63(4):288-93. PMID: 19367790.
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    27. Wallace PK, Tario JD, Fisher JL, Wallace SS, Ernstoff MS, Muirhead KA. Tracking antigen-driven responses by flow cytometry: monitoring proliferation by dye dilution. Cytometry A. 2008 Nov; 73(11):1019-34. PMID: 18785636.
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    28. Fisher JL. The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator. Neuropharmacology. 2009 Jan; 56(1):190-7. PMID: 18585399.
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    29. Bianchi MT, Botzolakis EJ, Haas KF, Fisher JL, Macdonald RL. Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. J Physiol. 2007 Nov 01; 584(Pt 3):769-87. PMID: 17884921.
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    30. Picton AJ, Fisher JL. Effect of the alpha subunit subtype on the macroscopic kinetic properties of recombinant GABA(A) receptors. Brain Res. 2007 Aug 24; 1165:40-9. PMID: 17658489.
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    31. Drafts BC, Fisher JL. Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital. J Pharmacol Exp Ther. 2006 Sep; 318(3):1094-101. PMID: 16728592.
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    32. Dass CR, Nadesapillai AP, Robin D, Howard ML, Fisher JL, Zhou H, Choong PF. Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma. Clin Exp Metastasis. 2005; 22(8):643-52. PMID: 16649073.
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    33. Fisher JL, Thomas-Mudge RJ, Elliott J, Hards DK, Sims NA, Slavin J, Martin TJ, Gillespie MT. Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Cancer Res. 2006 Apr 01; 66(7):3620-8. PMID: 16585187.
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    34. Fisher JL. The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics. J Physiol. 2004 Dec 01; 561(Pt 2):433-48. PMID: 15579538.
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    35. Häusler KD, Horwood NJ, Chuman Y, Fisher JL, Ellis J, Martin TJ, Rubin JS, Gillespie MT. Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res. 2004 Nov; 19(11):1873-81. PMID: 15476588.
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    36. Fisher JL. A mutation in the GABAA receptor alpha 1 subunit linked to human epilepsy affects channel gating properties. Neuropharmacology. 2004 Apr; 46(5):629-37. PMID: 14996540.
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    37. Drafts BC, Fisher JL. Structural determinants of the pharmacological properties of the GABAA receptor alpha6 subunit. J Pharmacol Exp Ther. 2004 Jun; 309(3):1108-15. PMID: 14762104.
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    38. Robinson RT, Drafts BC, Fisher JL. Fluoxetine increases GABA(A) receptor activity through a novel modulatory site. J Pharmacol Exp Ther. 2003 Mar; 304(3):978-84. PMID: 12604672.
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    39. Fisher JL. A lysine residue in the beta3 subunit contributes to the regulation of GABA(A) receptor activity by voltage. Mol Cell Neurosci. 2002 Aug; 20(4):683-94. PMID: 12213448.
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    40. Fisher JL. A histidine residue in the extracellular N-terminal domain of the GABA(A) receptor alpha5 subunit regulates sensitivity to inhibition by zinc. Neuropharmacology. 2002 Jun; 42(7):922-8. PMID: 12069902.
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    41. Fisher JL. Amiloride inhibition of gamma-aminobutyric acid(A) receptors depends upon the alpha subunit subtype. Mol Pharmacol. 2002 Jun; 61(6):1322-8. PMID: 12021393.
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    42. Fisher JL, Schmitt JF, Howard ML, Mackie PS, Choong PF, Risbridger GP. An in vivo model of prostate carcinoma growth and invasion in bone. Cell Tissue Res. 2002 Mar; 307(3):337-45. PMID: 11904770.
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