Yusuf Hannun to Tumor Necrosis Factor-alpha
This is a "connection" page, showing publications Yusuf Hannun has written about Tumor Necrosis Factor-alpha.
Connection Strength
3.849
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.308
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.295
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Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol. 2008 Oct; 74(4):1022-32.
Score: 0.255
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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem. 2007 Jan 12; 282(2):1384-96.
Score: 0.226
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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
Score: 0.221
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.180
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Ceramide kinase regulates TNF-a-induced immune responses in human monocytic cells. Sci Rep. 2021 04 15; 11(1):8259.
Score: 0.154
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Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a. Sci Rep. 2020 10 08; 10(1):16802.
Score: 0.148
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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res. 2018 07; 59(7):1219-1229.
Score: 0.125
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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20.
Score: 0.125
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The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611.
Score: 0.125
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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203.
Score: 0.118
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Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997 Jun 27; 272(26):16474-81.
Score: 0.118
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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997 Feb 03; 185(3):481-90.
Score: 0.115
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Tumor Necrosis Factor-a (TNFa)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem. 2015 Oct 16; 290(42):25356-73.
Score: 0.104
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Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63.
Score: 0.094
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Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem. 1993 Aug 25; 268(24):17762-6.
Score: 0.091
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Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679.
Score: 0.090
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Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem. 1991 Jan 05; 266(1):484-9.
Score: 0.075
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Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826.
Score: 0.071
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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88.
Score: 0.067
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.058
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Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8.
Score: 0.053
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Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7.
Score: 0.052
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.051
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A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51.
Score: 0.050
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Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202.
Score: 0.050
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.044
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Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25.
Score: 0.043
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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39.
Score: 0.042
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A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer. Nutrients. 2021 Jul 15; 13(7).
Score: 0.039
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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8.
Score: 0.037
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Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat. 2017 05; 130:47-56.
Score: 0.029
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Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9.
Score: 0.029
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Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.026
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Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem. 1994 Sep 23; 269(38):23530-7.
Score: 0.024
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Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71.
Score: 0.022
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Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. PLoS One. 2011 Apr 20; 6(4):e19037.
Score: 0.019
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A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 2009 Jan; 23(1):143-52.
Score: 0.016
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Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21.
Score: 0.013
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
Score: 0.013
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Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92.
Score: 0.009
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Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4.
Score: 0.008
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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8.
Score: 0.007
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Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6.
Score: 0.007