"Methylmalonic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
| Descriptor ID |
D008764
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| MeSH Number(s) |
D02.241.081.337.540.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methylmalonic Acid".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonic Acid".
This graph shows the total number of publications written about "Methylmalonic Acid" by people in this website by year, and whether "Methylmalonic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
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Below are the most recent publications written about "Methylmalonic Acid" by people in Profiles.
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High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations. Am J Clin Nutr. 2003 Feb; 77(2):433-40.
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Predictors of cobalamin deficiency in Guatemalan school children: diet, Helicobacter pylori, or bacterial overgrowth? J Pediatr Gastroenterol Nutr. 2003 Jan; 36(1):27-36.
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Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci. 1994 Nov; 308(5):276-83.
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Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med. 1987 May; 106(5):707-10.
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Laboratory tests in the diagnosis of vitamin B12 (cobalamin) deficiency. N C Med J. 1986 Mar; 47(3):118-20.
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Cisplatin neurotoxicity: failure to demonstrate vitamin B12 inactivation. Cancer Treat Rep. 1985 Apr; 69(4):453-5.