"Poly I-C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
| Descriptor ID |
D011070
|
| MeSH Number(s) |
D13.695.578.550.560.600 D13.695.578.550.650.600
|
| Concept/Terms |
Poly I-C- Poly I-C
- Poly I C
- Poly(I-C)
- Polyriboinosinic-Polyribocytidylic Acid
- Polyriboinosinic Polyribocytidylic Acid
- Polyribose Inosin-Cytidil
- Inosin-Cytidil, Polyribose
- Polyribose Inosin Cytidil
- Poly(rI).Poly(rC)
- Polyinosinic-Polycytidylic Acid
- Polyinosinic Polycytidylic Acid
- Polyinosinic-Polycytidylic Acid (High MW)
|
Below are MeSH descriptors whose meaning is more general than "Poly I-C".
Below are MeSH descriptors whose meaning is more specific than "Poly I-C".
This graph shows the total number of publications written about "Poly I-C" by people in this website by year, and whether "Poly I-C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Poly I-C" by people in Profiles.
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Bacterial and Viral Products Affect Differential Pattern Recognition Receptor Activation of Chicken Thrombocytes Evidenced through RNA Sequencing. J Immunol. 2017 07 15; 199(2):774-781.
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Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer. J Hematol Oncol. 2017 04 07; 10(1):82.
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NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice. J Immunol. 2013 Apr 01; 190(7):3639-47.
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Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Ga(i2) protein. Inflammation. 2012 Oct; 35(5):1611-7.
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Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C). J Immunol. 2009 Feb 15; 182(4):2030-40.
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The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into na?ve recipient mice. Vaccine. 2009 Jan 22; 27(4):549-57.
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The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine. 2006 Jun 12; 24(24):5119-32.
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Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. J Immunother. 2005 May-Jun; 28(3):220-8.
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Induction of antiviral immunity by double-stranded RNA in a marine invertebrate. J Virol. 2004 Oct; 78(19):10442-8.
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Treatment proposed for chronic fatigue syndrome; research continues to compile data on disorder. JAMA. 1991 Nov 20; 266(19):2667-8.