"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
|
| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
|
| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
|
Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 2 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 4 | 6 |
| 2014 | 2 | 2 | 4 |
| 2015 | 7 | 2 | 9 |
| 2017 | 2 | 1 | 3 |
| 2018 | 2 | 1 | 3 |
| 2020 | 0 | 3 | 3 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leptin" by people in Profiles.
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Bone Mass Accrual in First Six Months of Life: Impact of Maternal Diabetes, Infant Adiposity, and Cord Blood Adipokines. Calcif Tissue Int. 2022 09; 111(3):248-255.
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Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases. Neuropharmacology. 2022 02 01; 203:108877.
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Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain. Dis Model Mech. 2021 10 01; 14(10).
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Adipokines in early and mid-pregnancy and subsequent risk of gestational diabetes: a longitudinal study in a multiracial cohort. BMJ Open Diabetes Res Care. 2020 07; 8(1).
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Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2020 08 01; 319(2):E354-E362.
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In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood. Life Sci. 2020 Aug 01; 254:117764.
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Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women. Endocrine. 2019 01; 63(1):3-17.
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High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. Redox Biol. 2018 07; 17:1-15.
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Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. Metabolism. 2018 08; 85:32-37.
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Leptin, An Adipokine With Central Importance in the Global Obesity Problem. Glob Heart. 2018 06; 13(2):113-127.