"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
| Descriptor ID |
D015922
|
| MeSH Number(s) |
D12.776.124.486.274.050.270
|
| Concept/Terms |
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
|
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in this website by year, and whether "Complement C1q" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C1q" by people in Profiles.
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The complement and contact activation systems: partnership in pathogenesis beyond angioedema. Immunol Rev. 2016 11; 274(1):281-289.
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Anti-C1q antibodies in systemic lupus erythematosus. Lupus. 2015 Jan; 24(1):42-9.
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Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem. 2013 May 03; 288(18):12753-65.
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The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7.
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The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice. Arthritis Rheum. 2011 Apr; 63(4):1076-85.
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Complement inhibition alleviates paraquat-induced acute lung injury. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):834-42.
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Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun. 2009 Jul; 10(5):517-24.
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Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment. Mol Immunol. 2008 May; 45(9):2570-80.
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Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res. 2007 Jan; 84(1):82-91.
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Lupus susceptibility genes on human chromosome 1. Int Rev Immunol. 2000; 19(4-5):319-34.