"Lactosylceramides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.
| Descriptor ID |
D007790
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| MeSH Number(s) |
D02.065.313.612 D09.400.410.420.525.200.612 D10.390.470.675.200.612 D10.570.877.360.612.200.612
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lactosylceramides".
Below are MeSH descriptors whose meaning is more specific than "Lactosylceramides".
This graph shows the total number of publications written about "Lactosylceramides" by people in this website by year, and whether "Lactosylceramides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lactosylceramides" by people in Profiles.
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Diabetes and kidney dysfunction markedly alter the content of sphingolipids carried by circulating lipoproteins. J Clin Lipidol. 2022 Mar-Apr; 16(2):173-183.
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Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice. PLoS One. 2020; 15(3):e0230499.
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Analysis of sphingolipid composition in human vitreous from control and diabetic individuals. J Diabetes Complications. 2019 03; 33(3):195-201.
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Lactosylceramide contributes to mitochondrial dysfunction in diabetes. J Lipid Res. 2016 Apr; 57(4):546-62.
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FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. J Immunol. 2015 Dec 15; 195(12):5551-60.
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Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015 Aug 01; 309(3):F204-15.
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Lactosylceramide: a lipid second messenger in neuroinflammatory disease. J Neurochem. 2007 Nov; 103 Suppl 1:180-91.
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A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 08; 280(14):13742-51.
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A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J Neurosci. 2004 Jun 30; 24(26):5942-54.
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Sialylation of lacto-N-neohexaosylceramide by sialyltransferase from embryonic chicken muscle. Biochim Biophys Acta. 1986 Apr 15; 876(2):363-70.