"Sp1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
| Descriptor ID |
D016329
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| MeSH Number(s) |
D12.776.260.522.750.249 D12.776.930.375.750.249
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sp1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp1 Transcription Factor".
This graph shows the total number of publications written about "Sp1 Transcription Factor" by people in this website by year, and whether "Sp1 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2003 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 2 | 1 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sp1 Transcription Factor" by people in Profiles.
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Expression of GM-CSF Is Regulated by Fli-1 Transcription Factor, a Potential Drug Target. J Immunol. 2021 01 01; 206(1):59-66.
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MicroRNA-29b Inhibits Endometrial Fibrosis by Regulating the Sp1-TGF-?1/Smad-CTGF Axis in a Rat Model. Reprod Sci. 2016 Mar; 23(3):386-94.
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Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation. Mol Immunol. 2015 Feb; 63(2):566-73.
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Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. 2009 Feb 20; 284(8):5265-76.
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Regulation of Sp1 by cell cycle related proteins. Cell Cycle. 2008 Sep 15; 7(18):2856-67.
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The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G977-86.
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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47.
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Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. J Biol Chem. 2005 Aug 12; 280(32):28867-76.
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Analysis of the rat connexin 43 proximal promoter in neonatal cardiomyocytes. Gene. 2003 Dec 11; 322:123-36.
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Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res. 2003 Feb 01; 31(3):1097-107.