"Neuropilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
| Descriptor ID |
D039943
|
| MeSH Number(s) |
D12.776.543.750.590.750
|
| Concept/Terms |
Neuropilin-2- Neuropilin-2
- Neuropilin 2
- NRP2 Protein
- Npn-2 Protein
- Npn 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Neuropilin-2".
Below are MeSH descriptors whose meaning is more specific than "Neuropilin-2".
This graph shows the total number of publications written about "Neuropilin-2" by people in this website by year, and whether "Neuropilin-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neuropilin-2" by people in Profiles.
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Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer. Front Immunol. 2022; 13:830169.
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Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2021 08; 162(2):463-473.
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The neuropilin 2 isoform NRP2b uniquely supports TGF?-mediated progression in lung cancer. Sci Signal. 2017 01 17; 10(462).
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Neuropilin-2 Is upregulated in lung cancer cells during TGF-?1-induced epithelial-mesenchymal transition. Cancer Res. 2013 Dec 01; 73(23):7111-21.
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Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Neoplasia. 2005 Feb; 7(2):180-9.
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Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Neoplasia. 2003 Jan-Feb; 5(1):83-92.