"Novobiocin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
| Descriptor ID |
D009675
|
| MeSH Number(s) |
D03.383.663.283.446.139.500 D03.633.100.150.446.139.500 D09.408.554
|
| Concept/Terms |
Novobiocin- Novobiocin
- Streptonivicin
- Crystallinic Acid
Novobiocin Sodium- Novobiocin Sodium
- Sodium, Novobiocin
- Novobiocin, Monosodium Salt
- Monosodium Salt Novobiocin
|
Below are MeSH descriptors whose meaning is more general than "Novobiocin".
Below are MeSH descriptors whose meaning is more specific than "Novobiocin".
This graph shows the total number of publications written about "Novobiocin" by people in this website by year, and whether "Novobiocin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Novobiocin" by people in Profiles.
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Characterization of an extremely halotolerant Staphylococcus arlettae HPSSN35C isolated from Dwarka Beach, India. J Basic Microbiol. 2014 Aug; 54(8):843-50.
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Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrob Agents Chemother. 2010 May; 54(5):2112-8.
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Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome. Antimicrob Agents Chemother. 1993 Jun; 37(6):1334-42.
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Colonization of the female genital tract with Staphylococcus saprophyticus. J Clin Microbiol. 1992 Nov; 30(11):2975-9.
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Replication of plasmid R6K origin gamma in vitro. Dependence on dual initiator proteins and inhibition by transcription. J Biol Chem. 1991 Aug 25; 266(24):16056-62.
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Vaccinia virus encapsidates a novel topoisomerase with the properties of a eucaryotic type I enzyme. J Biol Chem. 1987 Jul 05; 262(19):9309-15.