"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
| Descriptor ID |
D020552
|
| MeSH Number(s) |
E05.196.401.153.150 E05.301.300.100.150 E05.393.560.150 E05.940.560.150
|
| Concept/Terms |
Comet Assay- Comet Assay
- Assay, Comet
- Assays, Comet
- Comet Assays
- Gel Electrophoresis, Single-Cell
- Electrophoreses, Single-Cell Gel
- Electrophoresis, Single-Cell Gel
- Gel Electrophoreses, Single-Cell
- Gel Electrophoresis, Single Cell
- Single-Cell Gel Electrophoreses
- Single-Cell Gel Electrophoresis
- Electrophoresis, Gel, Single-Cell
Alkaline Comet Assay- Alkaline Comet Assay
- Alkaline Comet Assays
- Assay, Alkaline Comet
- Assays, Alkaline Comet
- Comet Assay, Alkaline
- Comet Assays, Alkaline
- Alkaline Single-Cell Gel Electrophoresis Assay
- Alkaline Single Cell Gel Electrophoresis Assay
|
Below are MeSH descriptors whose meaning is more general than "Comet Assay".
Below are MeSH descriptors whose meaning is more specific than "Comet Assay".
This graph shows the total number of publications written about "Comet Assay" by people in this website by year, and whether "Comet Assay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Comet Assay" by people in Profiles.
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The role of base excision repair in the development of primary open angle glaucoma in the Polish population. Mutat Res. 2015 Aug; 778:26-40.
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DNA strand breaks (comet assay) in blood lymphocytes from wild bottlenose dolphins. Mar Pollut Bull. 2013 Dec 15; 77(1-2):355-60.
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Photofrin based photodynamic therapy and miR-99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo. PLoS One. 2013; 8(2):e55652.
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Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis. 2013 Feb; 34(2):277-86.
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Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. Biochem Pharmacol. 2010 Sep 15; 80(6):884-94.
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DNA damage and repair of head and neck cancer cells after radio- and chemotherapy. Z Naturforsch C J Biosci. 2009 Jul-Aug; 64(7-8):601-10.
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American ginseng suppresses inflammation and DNA damage associated with mouse colitis. Carcinogenesis. 2008 Dec; 29(12):2351-9.
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DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. J Biol Chem. 2005 Apr 01; 280(13):12927-34.
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Effect of multiple atrazine exposure profiles on hemocyte DNA integrity in the Eastern oyster (Crassostrea virginica). Bull Environ Contam Toxicol. 2004 Aug; 73(2):404-10.
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Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):143-8.