Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Descriptor ID |
D007968
|
| MeSH Number(s) |
C02.182.525.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.430.520.750.500 C10.228.140.695.750 C10.228.228.245.340.500 C10.228.228.399.750.500 C10.314.450
|
| Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- Progressive Multifocal Leukoencephalopathy
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
|
Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis, Viral [C02.182.525]
- Leukoencephalopathy, Progressive Multifocal [C02.182.525.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Encephalitis [C10.228.140.430]
- Infectious Encephalitis [C10.228.140.430.520]
- Encephalitis, Viral [C10.228.140.430.520.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.430.520.750.500]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.500]
- Infectious Encephalitis [C10.228.228.399]
- Encephalitis, Viral [C10.228.228.399.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.399.750.500]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in this website by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 3 | 0 | 3 |
| 2011 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles.
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Rituximab-Associated Progressive Multifocal Leukoencephalopathy: A Twenty-Year Update. Cancer Treat Res. 2022; 184:103-111.
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Progressive multifocal leukoencephalopathy in patients treated with rituximab: a 20-year review from the Southern Network on Adverse Reactions. Lancet Haematol. 2021 Aug; 8(8):e593-e604.
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Brain Lesion in the Setting of Chronic Rituximab Treatment. JAMA Oncol. 2020 07 01; 6(7):1093-1094.
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Progressive multi-focal leucoencephalopathy among ibrutinib-treated persons with chronic lymphocytic leukaemia. Br J Haematol. 2018 01; 180(2):301-304.
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Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA's adverse event reporting system. Expert Opin Drug Saf. 2016 Aug; 15(8):1003-11.
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Reply to magnetic resonance imaging-based diagnosis of progressive multifocal leukoencephalopathy in a patient with non-Hodgkin lymphoma after therapy with cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab. Cancer. 2014 Dec 15; 120(24):4006-7.
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Progressive multifocal leukoencephalopathy associated with brentuximab vedotin therapy: a report of 5 cases from the Southern Network on Adverse Reactions (SONAR) project. Cancer. 2014 Aug 15; 120(16):2464-71.
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Pharmacovigilance and PML in the oncology setting. Cleve Clin J Med. 2011 Nov; 78 Suppl 2:S13-7.
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Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Lancet Oncol. 2009 Aug; 10(8):816-24.
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Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood. 2009 May 14; 113(20):4834-40.