Yusuf Hannun to Sphingomyelin Phosphodiesterase
This is a "connection" page, showing publications Yusuf Hannun has written about Sphingomyelin Phosphodiesterase.
Connection Strength
17.447
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Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47.
Score: 0.586
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Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850.
Score: 0.566
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The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502.
Score: 0.555
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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res. 2018 07; 59(7):1219-1229.
Score: 0.522
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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5549-E5558.
Score: 0.492
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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. J Lipid Res. 2016 05; 57(5):868-81.
Score: 0.451
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P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest. Cell Death Dis. 2015 Oct 29; 6:e1947.
Score: 0.439
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A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis. EMBO Mol Med. 2015 Jun; 7(6):692-4.
Score: 0.427
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Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39.
Score: 0.412
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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41.
Score: 0.409
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Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. PLoS One. 2014; 9(8):e105830.
Score: 0.404
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Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. J Biol Chem. 2014 Aug 08; 289(32):22401-12.
Score: 0.399
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Sphingolipid metabolism and neutral sphingomyelinases. Handb Exp Pharmacol. 2013; (215):57-76.
Score: 0.361
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The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.337
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712.
Score: 0.323
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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71.
Score: 0.322
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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76.
Score: 0.321
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.320
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.317
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A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. J Biol Chem. 2011 Feb 04; 286(5):3777-88.
Score: 0.312
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The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul. 2011; 51(1):51-8.
Score: 0.310
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.307
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Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. Biochim Biophys Acta. 2010 Dec; 1801(12):1361-74.
Score: 0.306
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The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010 Jul; 10(5):454-66.
Score: 0.303
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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30.
Score: 0.303
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Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal. 2009 Jun; 21(6):836-46.
Score: 0.281
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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol. 2008 Apr 21; 181(2):335-50.
Score: 0.261
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Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. J Lipid Res. 2008 May; 49(5):922-8.
Score: 0.258
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A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 2008 Jan; 22(1):183-93.
Score: 0.248
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Analysis of membrane topology of neutral sphingomyelinase 2. FEBS Lett. 2007 Apr 03; 581(7):1323-8.
Score: 0.241
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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.240
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Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007 Mar 30; 282(13):10047-10056.
Score: 0.239
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Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. Arch Biochem Biophys. 2007 Mar 15; 459(2):295-300.
Score: 0.236
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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem. 2007 Jan 12; 282(2):1384-96.
Score: 0.235
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The extended family of neutral sphingomyelinases. Biochemistry. 2006 Sep 26; 45(38):11247-56.
Score: 0.234
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Neutral sphingomyelinases and nSMase2: bridging the gaps. Biochim Biophys Acta. 2006 Dec; 1758(12):1893-901.
Score: 0.231
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Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46.
Score: 0.230
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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11.
Score: 0.197
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Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44.
Score: 0.195
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.182
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
Score: 0.159
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
Score: 0.157
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Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a. Sci Rep. 2020 10 08; 10(1):16802.
Score: 0.155
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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630.
Score: 0.150
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Purification of rat brain membrane neutral sphingomyelinase. Methods Enzymol. 2000; 311:156-64.
Score: 0.147
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Sphingomyelinase assay using radiolabeled substrate. Methods Enzymol. 2000; 311:164-7.
Score: 0.147
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Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9.
Score: 0.147
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Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7.
Score: 0.145
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Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J Biol Chem. 1998 Dec 18; 273(51):34472-9.
Score: 0.136
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Functions of neutral ceramidase in the Golgi apparatus. J Lipid Res. 2018 11; 59(11):2116-2125.
Score: 0.134
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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20.
Score: 0.131
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7.
Score: 0.123
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Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032.
Score: 0.107
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GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis. 2015 May; 240(1):163-73.
Score: 0.105
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Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1994 Feb 11; 269(6):4070-7.
Score: 0.097
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Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72.
Score: 0.094
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Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67.
Score: 0.094
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.092
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
Score: 0.090
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Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther. 2012 Aug; 23(8):891-902.
Score: 0.088
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Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 2012 May; 136(1):30-45.
Score: 0.086
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.086
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A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25; 194(2):277-89.
Score: 0.082
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Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826.
Score: 0.074
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The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1112-7.
Score: 0.073
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Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 2010 May 03; 584(9):1887-94.
Score: 0.072
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Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta. 2009 Aug; 1791(8):730-9.
Score: 0.070
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Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):367-75.
Score: 0.069
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Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008 Oct 24; 283(43):28806-16.
Score: 0.066
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Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim Biophys Acta. 2007 Dec; 1771(12):1418-28.
Score: 0.063
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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
Score: 0.057
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Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem. 2003 Aug 29; 278(35):32733-43.
Score: 0.046
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Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25.
Score: 0.045
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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39.
Score: 0.044
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Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903.
Score: 0.040
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Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem. 2000 Dec 15; 275(50):39793-8.
Score: 0.039
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Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J Biol Chem. 2000 May 12; 275(19):14760-6.
Score: 0.038
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Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. Biochem J. 2000 Mar 01; 346 Pt 2:537-43.
Score: 0.037
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Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11.
Score: 0.034
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The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43.
Score: 0.034
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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem. 1998 Jun 05; 273(23):14550-9.
Score: 0.033
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Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60.
Score: 0.033
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Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5.
Score: 0.032
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Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997 Jun 27; 272(26):16474-81.
Score: 0.031
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Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem. 1997 Apr 11; 272(15):9609-12.
Score: 0.030
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Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.027
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Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem. 1994 Sep 23; 269(38):23530-7.
Score: 0.025
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Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63.
Score: 0.024
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Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011; 6(6):e20411.
Score: 0.020
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Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr; 5(7):2068-77.
Score: 0.020
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Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem. 1991 Jan 05; 266(1):484-9.
Score: 0.020
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Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem. 1989 Nov 15; 264(32):19076-80.
Score: 0.018
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Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. Biochemistry. 2008 Oct 28; 47(43):11222-30.
Score: 0.017
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Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem. 2008 Sep 26; 283(39):26509-17.
Score: 0.017
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Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem. 2008 May 16; 283(20):13538-48.
Score: 0.016
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De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 2008 Jun; 86(1-4):41-8.
Score: 0.016
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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2008 Feb; 61(2):231-42.
Score: 0.015
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.015
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Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes. 2006 Sep; 55(9):2579-87.
Score: 0.015
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Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther. 2006 Nov; 14(5):627-36.
Score: 0.015
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A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51.
Score: 0.013
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Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79.
Score: 0.010
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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.010
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Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995 Aug 01; 182(2):599-604.
Score: 0.007