Sphingomyelin Phosphodiesterase
"Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
| Descriptor ID |
D013108
|
| MeSH Number(s) |
D08.811.277.352.640.750
|
| Concept/Terms |
Sphingomyelin Phosphodiesterase- Sphingomyelin Phosphodiesterase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase C
- Sphingomyelinase
- Sphingomyelin Cholinephosphohydrolase
|
Below are MeSH descriptors whose meaning is more general than "Sphingomyelin Phosphodiesterase".
Below are MeSH descriptors whose meaning is more specific than "Sphingomyelin Phosphodiesterase".
This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 1 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 2 | 2 | 4 |
| 1998 | 4 | 2 | 6 |
| 1999 | 3 | 1 | 4 |
| 2000 | 3 | 2 | 5 |
| 2001 | 0 | 3 | 3 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 3 | 0 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 5 | 3 | 8 |
| 2007 | 4 | 4 | 8 |
| 2008 | 3 | 4 | 7 |
| 2009 | 3 | 3 | 6 |
| 2010 | 7 | 1 | 8 |
| 2011 | 7 | 2 | 9 |
| 2012 | 5 | 0 | 5 |
| 2013 | 5 | 1 | 6 |
| 2014 | 4 | 1 | 5 |
| 2015 | 4 | 0 | 4 |
| 2016 | 3 | 0 | 3 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 4 | 0 | 4 |
| 2020 | 2 | 2 | 4 |
| 2021 | 2 | 3 | 5 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles.
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Sphingomyelinases in retinas and optic nerve heads: Effects of ocular hypertension and ischemia. Exp Eye Res. 2022 11; 224:109250.
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Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss. J Periodontal Res. 2022 Jan; 57(1):173-185.
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Evidence for ceramide induced cytotoxicity in retinal ganglion cells. Exp Eye Res. 2021 10; 211:108762.
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
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Lipid presentation by the protein C receptor links coagulation with autoimmunity. Science. 2021 03 12; 371(6534).
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
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Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a. Sci Rep. 2020 10 08; 10(1):16802.
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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630.
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Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis. Oral Dis. 2020 Apr; 26(3):637-646.
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Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47.