Connection

Yusuf Hannun to Sphingosine

This is a "connection" page, showing publications Yusuf Hannun has written about Sphingosine.
Connection Strength

9.475
  1. Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146.
    View in: PubMed
    Score: 0.544
  2. Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae. J Lipid Res. 2018 01; 59(1):162-170.
    View in: PubMed
    Score: 0.508
  3. Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491.
    View in: PubMed
    Score: 0.434
  4. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
    View in: PubMed
    Score: 0.319
  5. Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
    View in: PubMed
    Score: 0.308
  6. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5.
    View in: PubMed
    Score: 0.214
  7. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
    View in: PubMed
    Score: 0.203
  8. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
    View in: PubMed
    Score: 0.189
  9. Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787.
    View in: PubMed
    Score: 0.184
  10. A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane. J Lipid Res. 2023 02; 64(2):100322.
    View in: PubMed
    Score: 0.181
  11. Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8.
    View in: PubMed
    Score: 0.170
  12. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
    View in: PubMed
    Score: 0.170
  13. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66.
    View in: PubMed
    Score: 0.159
  14. Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875.
    View in: PubMed
    Score: 0.157
  15. Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268.
    View in: PubMed
    Score: 0.155
  16. Synthesis of key precursors of radiolabeled sphingolipids. Methods Enzymol. 2000; 311:518-35.
    View in: PubMed
    Score: 0.148
  17. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
    View in: PubMed
    Score: 0.148
  18. Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
    View in: PubMed
    Score: 0.141
  19. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
    View in: PubMed
    Score: 0.131
  20. Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
    View in: PubMed
    Score: 0.129
  21. An intrinsic lipid-binding interface controls sphingosine kinase 1 function. J Lipid Res. 2018 03; 59(3):462-474.
    View in: PubMed
    Score: 0.129
  22. Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856.
    View in: PubMed
    Score: 0.128
  23. Sphingosine 1-phosphate activation of ERM contributes to vascular calcification. J Lipid Res. 2018 01; 59(1):69-78.
    View in: PubMed
    Score: 0.128
  24. Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4.
    View in: PubMed
    Score: 0.124
  25. Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat. 2017 05; 130:47-56.
    View in: PubMed
    Score: 0.122
  26. Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. Oncotarget. 2016 Apr 05; 7(14):18440-57.
    View in: PubMed
    Score: 0.114
  27. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9.
    View in: PubMed
    Score: 0.109
  28. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015 Nov; 29(11):4654-69.
    View in: PubMed
    Score: 0.109
  29. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 1995 Feb 14; 34(6):1885-92.
    View in: PubMed
    Score: 0.105
  30. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
    View in: PubMed
    Score: 0.099
  31. Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014 May 09; 289(19):13142-54.
    View in: PubMed
    Score: 0.099
  32. Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. Biochim Biophys Acta. 1994 Mar 10; 1221(1):54-60.
    View in: PubMed
    Score: 0.099
  33. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15; 294 ( Pt 3):699-703.
    View in: PubMed
    Score: 0.095
  34. Sphingosine-1-phosphate receptor 2. FEBS J. 2013 Dec; 280(24):6354-66.
    View in: PubMed
    Score: 0.095
  35. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J. 2013 Aug; 27(8):3155-66.
    View in: PubMed
    Score: 0.093
  36. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72.
    View in: PubMed
    Score: 0.091
  37. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25; 267(33):23459-62.
    View in: PubMed
    Score: 0.090
  38. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):124-30.
    View in: PubMed
    Score: 0.089
  39. Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action. J Biol Chem. 1992 Jul 25; 267(21):15246-51.
    View in: PubMed
    Score: 0.088
  40. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov 01; 131(9):2034-43.
    View in: PubMed
    Score: 0.086
  41. Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. J Biol Chem. 2012 Mar 23; 287(13):10145-10155.
    View in: PubMed
    Score: 0.085
  42. Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. BMC Cancer. 2011 Nov 07; 11:477.
    View in: PubMed
    Score: 0.084
  43. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J. 1991 Sep 01; 278 ( Pt 2):387-92.
    View in: PubMed
    Score: 0.083
  44. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62.
    View in: PubMed
    Score: 0.081
  45. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem. 2011 May 06; 286(18):15929-42.
    View in: PubMed
    Score: 0.080
  46. Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28.
    View in: PubMed
    Score: 0.079
  47. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):683-91.
    View in: PubMed
    Score: 0.078
  48. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol. 2010; 6:349.
    View in: PubMed
    Score: 0.074
  49. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
    View in: PubMed
    Score: 0.074
  50. Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem. 2009 May 08; 284(19):12972-8.
    View in: PubMed
    Score: 0.070
  51. Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008 Aug; 9(8):653-61.
    View in: PubMed
    Score: 0.067
  52. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb; 9(2):139-50.
    View in: PubMed
    Score: 0.065
  53. Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10.
    View in: PubMed
    Score: 0.064
  54. Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer. 2008 Jan 15; 98(1):98-105.
    View in: PubMed
    Score: 0.064
  55. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem. 1987 Oct 05; 262(28):13620-6.
    View in: PubMed
    Score: 0.063
  56. Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J Biol Chem. 2007 Apr 20; 282(16):12330-40.
    View in: PubMed
    Score: 0.061
  57. Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium. J Lipid Res. 2007 Mar; 48(3):600-8.
    View in: PubMed
    Score: 0.060
  58. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 1986 Sep 25; 261(27):12604-9.
    View in: PubMed
    Score: 0.059
  59. Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
    View in: PubMed
    Score: 0.058
  60. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006 Oct; 112(1):171-83.
    View in: PubMed
    Score: 0.058
  61. Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31.
    View in: PubMed
    Score: 0.057
  62. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21.
    View in: PubMed
    Score: 0.056
  63. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
    View in: PubMed
    Score: 0.055
  64. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
    View in: PubMed
    Score: 0.054
  65. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001.
    View in: PubMed
    Score: 0.051
  66. Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004 Jun; 4(4):405-18.
    View in: PubMed
    Score: 0.050
  67. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62.
    View in: PubMed
    Score: 0.044
  68. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem. 2001 Sep 21; 276(38):35614-21.
    View in: PubMed
    Score: 0.041
  69. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
    View in: PubMed
    Score: 0.041
  70. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem. 2000 Jun 09; 275(23):17229-32.
    View in: PubMed
    Score: 0.038
  71. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84.
    View in: PubMed
    Score: 0.038
  72. Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8.
    View in: PubMed
    Score: 0.034
  73. Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
    View in: PubMed
    Score: 0.033
  74. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J Immunol. 1998 Apr 01; 160(7):3528-33.
    View in: PubMed
    Score: 0.033
  75. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem. 1997 Nov 07; 272(45):28690-4.
    View in: PubMed
    Score: 0.032
  76. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90.
    View in: PubMed
    Score: 0.032
  77. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem. 1997 Jun 27; 272(26):16295-300.
    View in: PubMed
    Score: 0.031
  78. Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. Bioorg Med Chem. 1996 Jul; 4(7):1035-43.
    View in: PubMed
    Score: 0.029
  79. Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016 Mar 15; 473(6):743-55.
    View in: PubMed
    Score: 0.028
  80. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
    View in: PubMed
    Score: 0.028
  81. A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13.
    View in: PubMed
    Score: 0.027
  82. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998.
    View in: PubMed
    Score: 0.026
  83. Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35.
    View in: PubMed
    Score: 0.025
  84. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014 Jan; 25(1):196-211.
    View in: PubMed
    Score: 0.024
  85. Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72.
    View in: PubMed
    Score: 0.024
  86. A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
    View in: PubMed
    Score: 0.023
  87. Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem. 1992 Mar 15; 267(8):5048-51.
    View in: PubMed
    Score: 0.022
  88. Activation of casein kinase II by sphingosine. J Biol Chem. 1991 Nov 15; 266(32):21773-6.
    View in: PubMed
    Score: 0.021
  89. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res. 2010 Oct; 51(10):3074-87.
    View in: PubMed
    Score: 0.019
  90. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80.
    View in: PubMed
    Score: 0.019
  91. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2010 Feb; 303(2):163-8.
    View in: PubMed
    Score: 0.018
  92. Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J Biol Chem. 1989 Nov 05; 264(31):18440-4.
    View in: PubMed
    Score: 0.018
  93. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
    View in: PubMed
    Score: 0.018
  94. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45.
    View in: PubMed
    Score: 0.018
  95. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 1989 Jan 27; 243(4890):500-7.
    View in: PubMed
    Score: 0.017
  96. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8.
    View in: PubMed
    Score: 0.017
  97. Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J. 2009 Feb; 23(2):405-14.
    View in: PubMed
    Score: 0.017
  98. A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 2009 Jan; 23(1):143-52.
    View in: PubMed
    Score: 0.017
  99. Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27.
    View in: PubMed
    Score: 0.016
  100. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res. 2007 Dec; 17(12):1030-40.
    View in: PubMed
    Score: 0.016
  101. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 2007 Sep 06; 449(7158):62-7.
    View in: PubMed
    Score: 0.016
  102. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007 Oct 18; 256(1):101-11.
    View in: PubMed
    Score: 0.016
  103. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4.
    View in: PubMed
    Score: 0.015
  104. Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
    View in: PubMed
    Score: 0.015
  105. Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers. Soc Gen Physiol Ser. 1987; 42:229-40.
    View in: PubMed
    Score: 0.015
  106. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost. 2006 Dec; 4(12):2704-9.
    View in: PubMed
    Score: 0.015
  107. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5.
    View in: PubMed
    Score: 0.015
  108. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9.
    View in: PubMed
    Score: 0.014
  109. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31.
    View in: PubMed
    Score: 0.014
  110. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8.
    View in: PubMed
    Score: 0.014
  111. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67.
    View in: PubMed
    Score: 0.013
  112. Regulation of membrane release in apoptosis. Biochem J. 1998 Sep 01; 334 ( Pt 2):479-85.
    View in: PubMed
    Score: 0.008
  113. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997 Nov; 151(5):1257-63.
    View in: PubMed
    Score: 0.008
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.