Yusuf Hannun to Dose-Response Relationship, Drug
This is a "connection" page, showing publications Yusuf Hannun has written about Dose-Response Relationship, Drug.
Connection Strength
1.052
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Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases. Breast Cancer Res. 2021 07 27; 23(1):76.
Score: 0.140
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
Score: 0.135
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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831.
Score: 0.117
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Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075.
Score: 0.116
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.066
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Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem. 2003 Aug 29; 278(35):32733-43.
Score: 0.040
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.039
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Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem. 2001 Apr 27; 276(17):13606-14.
Score: 0.034
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Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem. 2000 Dec 15; 275(50):39793-8.
Score: 0.034
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
Score: 0.033
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Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41.
Score: 0.031
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7.
Score: 0.026
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Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9.
Score: 0.023
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GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis. 2015 May; 240(1):163-73.
Score: 0.023
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Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994 Jul 29; 269(30):19605-9.
Score: 0.022
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Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61.
Score: 0.020
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.020
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Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J. 2013 Aug; 27(8):3155-66.
Score: 0.020
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Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
Score: 0.016
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Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99.
Score: 0.012
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.011
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Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202.
Score: 0.011
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Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67.
Score: 0.011
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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004 May 07; 279(19):20546-54.
Score: 0.010
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Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92.
Score: 0.010
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Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
Score: 0.010
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Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82.
Score: 0.010
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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.009
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Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27.
Score: 0.003