Yusuf Hannun to Enzyme Activation
This is a "connection" page, showing publications Yusuf Hannun has written about Enzyme Activation.
Connection Strength
2.258
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The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502.
Score: 0.136
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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. PLoS One. 2017; 12(9):e0184818.
Score: 0.123
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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PLoS One. 2015; 10(8):e0136633.
Score: 0.106
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Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res. 2012 Aug; 53(8):1513-21.
Score: 0.085
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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71.
Score: 0.079
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.079
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Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim Biophys Acta. 2007 Dec; 1771(12):1418-28.
Score: 0.062
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A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 2008 Jan; 22(1):183-93.
Score: 0.061
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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem. 2007 Jul 13; 282(28):20647-56.
Score: 0.060
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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.059
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Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. Arch Biochem Biophys. 2007 Mar 15; 459(2):295-300.
Score: 0.058
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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem. 2007 Jan 12; 282(2):1384-96.
Score: 0.058
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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006 Dec 01; 281(48):36793-802.
Score: 0.057
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The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem. 2005 Feb 25; 280(8):7170-7.
Score: 0.051
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Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem. 2004 Mar 19; 279(12):11537-45.
Score: 0.047
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The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506.
Score: 0.047
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cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54.
Score: 0.047
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
Score: 0.037
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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84.
Score: 0.037
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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem. 1999 Jul 16; 274(29):20313-7.
Score: 0.035
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An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem. 1998 Oct 09; 273(41):26870-4.
Score: 0.033
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Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8.
Score: 0.033
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Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem. 1996 Jun 28; 271(26):15823-30.
Score: 0.028
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Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 1996 Jun; 7(6):765-74.
Score: 0.028
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(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24; 271(21):12646-54.
Score: 0.028
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CHK1 regulates NF-?B signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. 2016 Apr 05; 7(14):18159-70.
Score: 0.028
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Tumor Necrosis Factor-a (TNFa)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem. 2015 Oct 16; 290(42):25356-73.
Score: 0.027
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal. 1995 Mar; 7(3):171-84.
Score: 0.026
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Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35.
Score: 0.024
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Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63.
Score: 0.024
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Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1994 Feb 11; 269(6):4070-7.
Score: 0.024
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Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15; 294 ( Pt 3):699-703.
Score: 0.023
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Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679.
Score: 0.023
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Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30.
Score: 0.023
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.023
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Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem. 1993 Mar 05; 268(7):5063-8.
Score: 0.022
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Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res. 1993; 25:91-104.
Score: 0.022
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Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action. J Biol Chem. 1992 Jul 25; 267(21):15246-51.
Score: 0.021
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.021
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Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. J Biol Chem. 1992 Feb 25; 267(6):3605-12.
Score: 0.021
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Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion. Mol Pharmacol. 1992 Feb; 41(2):382-6.
Score: 0.021
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Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS Lett. 1991 Nov 04; 292(1-2):98-102.
Score: 0.020
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Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75.
Score: 0.020
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Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28.
Score: 0.019
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The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1112-7.
Score: 0.018
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Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
Score: 0.018
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Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8.
Score: 0.017
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Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem. 2008 May 23; 283(21):14335-44.
Score: 0.016
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De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 2008 Jun; 86(1-4):41-8.
Score: 0.016
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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2008 Feb; 61(2):231-42.
Score: 0.015
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.015
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Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. J Biol Chem. 1986 Jul 15; 261(20):9341-7.
Score: 0.014
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Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem. 1986 Jun 05; 261(16):7184-90.
Score: 0.014
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Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9.
Score: 0.014
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Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31.
Score: 0.014
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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4.
Score: 0.014
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
Score: 0.013
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Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7.
Score: 0.013
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Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202.
Score: 0.013
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Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
Score: 0.011
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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31.
Score: 0.011
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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39.
Score: 0.011
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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62.
Score: 0.011
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
Score: 0.010
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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8.
Score: 0.009
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FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 1999 Dec; 10(12):797-804.
Score: 0.009
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Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):199-204.
Score: 0.008
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Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem. 1997 Jun 27; 272(26):16295-300.
Score: 0.008
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Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35.
Score: 0.007
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12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18.
Score: 0.007
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Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.007
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Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8443-7.
Score: 0.007
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The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res. 1993; 25:43-64.
Score: 0.006
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Activation of casein kinase II by sphingosine. J Biol Chem. 1991 Nov 15; 266(32):21773-6.
Score: 0.005
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Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1184-8.
Score: 0.003