"Enzyme Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
| Descriptor ID |
D004789
|
| MeSH Number(s) |
G02.111.263 G03.328
|
| Concept/Terms |
Enzyme Activation- Enzyme Activation
- Activation, Enzyme
- Activations, Enzyme
- Enzyme Activations
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Activation".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Activation".
This graph shows the total number of publications written about "Enzyme Activation" by people in this website by year, and whether "Enzyme Activation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 22 | 22 |
| 1996 | 0 | 18 | 18 |
| 1997 | 0 | 13 | 13 |
| 1998 | 0 | 18 | 18 |
| 1999 | 0 | 28 | 28 |
| 2000 | 1 | 22 | 23 |
| 2001 | 0 | 18 | 18 |
| 2002 | 0 | 18 | 18 |
| 2003 | 0 | 38 | 38 |
| 2004 | 0 | 21 | 21 |
| 2005 | 1 | 27 | 28 |
| 2006 | 0 | 43 | 43 |
| 2007 | 1 | 31 | 32 |
| 2008 | 1 | 19 | 20 |
| 2009 | 0 | 21 | 21 |
| 2010 | 0 | 25 | 25 |
| 2011 | 1 | 21 | 22 |
| 2012 | 0 | 18 | 18 |
| 2013 | 0 | 16 | 16 |
| 2014 | 1 | 12 | 13 |
| 2015 | 1 | 14 | 15 |
| 2016 | 1 | 14 | 15 |
| 2017 | 0 | 7 | 7 |
| 2018 | 0 | 8 | 8 |
| 2019 | 0 | 5 | 5 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Enzyme Activation" by people in Profiles.
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PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021 06 08; 12(1):3444.
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PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons. Neurochem Int. 2021 Sep; 148:105077.
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Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. J Neurosci. 2020 10 28; 40(44):8463-8477.
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
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Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2021 08; 162(2):463-473.
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Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization. Toxicol Appl Pharmacol. 2020 06 01; 396:114982.
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JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells. Biochem Pharmacol. 2020 01; 171:113728.
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Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues. ACS Chem Biol. 2019 05 17; 14(5):1020-1029.
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The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502.
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Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury. J Lipid Res. 2019 03; 60(3):609-623.