Connection

Patrick Woster to Enzyme Inhibitors

This is a "connection" page, showing publications Patrick Woster has written about Enzyme Inhibitors.
Connection Strength

1.586
  1. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorg Med Chem. 2015 Apr 01; 23(7):1601-12.
    View in: PubMed
    Score: 0.376
  2. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1. J Med Chem. 2012 Sep 13; 55(17):7378-91.
    View in: PubMed
    Score: 0.318
  3. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. J Med Chem. 2008 Apr 24; 51(8):2447-56.
    View in: PubMed
    Score: 0.233
  4. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5):557-572.
    View in: PubMed
    Score: 0.120
  5. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. Bioorg Med Chem. 1996 Jun; 4(6):825-36.
    View in: PubMed
    Score: 0.103
  6. Design of small molecule epigenetic modulators. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):21-32.
    View in: PubMed
    Score: 0.086
  7. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Amino Acids. 2014 Mar; 46(3):585-94.
    View in: PubMed
    Score: 0.083
  8. Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73.
    View in: PubMed
    Score: 0.064
  9. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8023-8.
    View in: PubMed
    Score: 0.055
  10. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 1999 Mar; 65(3):237-44.
    View in: PubMed
    Score: 0.031
  11. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos. 1997 Nov; 25(11):1228-33.
    View in: PubMed
    Score: 0.028
  12. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013 Feb 22; 15:e3.
    View in: PubMed
    Score: 0.021
  13. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012 Mar 11; 18(4):605-11.
    View in: PubMed
    Score: 0.019
  14. A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2009 Oct 01; 69(19):7689-95.
    View in: PubMed
    Score: 0.016
  15. Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology (Reading). 2004 May; 150(Pt 5):1215-1224.
    View in: PubMed
    Score: 0.011
  16. The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug; 384(8):1195-201.
    View in: PubMed
    Score: 0.011
  17. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem Biophys Res Commun. 2003 May 16; 304(4):605-11.
    View in: PubMed
    Score: 0.010
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.