Patrick Woster to Polyamines
This is a "connection" page, showing publications Patrick Woster has written about Polyamines.
Connection Strength
5.262
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Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods Mol Biol. 2011; 720:475-91.
Score: 0.348
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Design of polyamine-based therapeutic agents: new targets and new directions. Essays Biochem. 2009 Nov 04; 46:77-94.
Score: 0.321
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Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73.
Score: 0.316
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Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimicrob Agents Chemother. 2009 Jun; 53(6):2599-604.
Score: 0.306
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Polyamine-based analogues as biochemical probes and potential therapeutics. Biochem Soc Trans. 2007 Apr; 35(Pt 2):356-63.
Score: 0.268
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Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Med Sci (Basel). 2022 08 30; 10(3).
Score: 0.195
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Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade. J Immunother. 2021 10 01; 44(8):283-291.
Score: 0.183
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Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem. 2001 Jan 04; 44(1):1-26.
Score: 0.174
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1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization. J Med Chem. 1999 Apr 22; 42(8):1415-21.
Score: 0.155
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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9.
Score: 0.153
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Polyamine catabolism and oxidative damage. J Biol Chem. 2018 11 30; 293(48):18736-18745.
Score: 0.149
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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677.
Score: 0.148
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Targeting polyamine metabolism for cancer therapy and prevention. Biochem J. 2016 10 01; 473(19):2937-53.
Score: 0.130
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Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. Bioorg Med Chem. 1996 Jun; 4(6):825-36.
Score: 0.127
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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorg Med Chem. 2015 Aug 15; 23(16):5131-43.
Score: 0.115
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Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother Pharmacol. 1995; 36(1):69-74.
Score: 0.115
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Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. J Med Chem. 1993 Oct 01; 36(20):2998-3004.
Score: 0.105
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Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism. Mol Cancer Ther. 2013 Oct; 12(10):2088-99.
Score: 0.104
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Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013 Feb 22; 15:e3.
Score: 0.101
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Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis. J Inorg Biochem. 2012 Mar; 108:1-7.
Score: 0.093
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Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. J Biol Chem. 2011 Dec 16; 286(50):43301-12.
Score: 0.092
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Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. J Med Chem. 2011 Oct 13; 54(19):6624-33.
Score: 0.091
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Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15354-9.
Score: 0.091
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Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids. 2012 Feb; 42(2-3):887-98.
Score: 0.091
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Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer. 2010 Oct 14; 10:555.
Score: 0.086
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Polyamine analogues targeting epigenetic gene regulation. Essays Biochem. 2009 Nov 04; 46:95-110.
Score: 0.080
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Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8023-8.
Score: 0.067
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Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity. Cancer Chemother Pharmacol. 2005 Jul; 56(1):83-90.
Score: 0.058
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Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. Biochem J. 2005 Mar 15; 386(Pt 3):543-7.
Score: 0.058
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Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc West Pharmacol Soc. 2005; 48:24-30.
Score: 0.057
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Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology (Reading). 2004 May; 150(Pt 5):1215-1224.
Score: 0.055
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Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother Pharmacol. 2003 Nov; 52(5):383-90.
Score: 0.052
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Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite. Biochem J. 2002 Oct 01; 367(Pt 1):307-12.
Score: 0.049
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Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure. Clin Cancer Res. 2002 Aug; 8(8):2684-9.
Score: 0.049
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Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clin Cancer Res. 2002 May; 8(5):1241-7.
Score: 0.048
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The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. Cancer Gene Ther. 2022 07; 29(7):940-950.
Score: 0.046
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Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 2001 Jul 15; 61(14):5370-3.
Score: 0.045
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Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1613-7.
Score: 0.045
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Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. J Mol Biol. 2000 Apr 07; 297(4):933-45.
Score: 0.041
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Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. J Cell Physiol. 2000 Feb; 182(2):209-13.
Score: 0.041
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Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells. Clin Cancer Res. 2000 Jan; 6(1):17-23.
Score: 0.041
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Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment. Endocr Relat Cancer. 1999 Mar; 6(1):69-73.
Score: 0.038
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Comparison of polyamine analogue toxicity in two cell lines (HL-60 & MCF-7). Biochem Soc Trans. 1998 Nov; 26(4):S371.
Score: 0.037
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Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells. Cancer Res. 1998 Jul 01; 58(13):2711-4.
Score: 0.037
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The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11557-62.
Score: 0.035
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Polyamine analogue induction of programmed cell death in human lung tumor cells. Clin Cancer Res. 1996 Mar; 2(3):441-6.
Score: 0.031
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Photoaffinity labeling of a cell surface polyamine binding protein. J Biol Chem. 1995 Dec 01; 270(48):28705-11.
Score: 0.031
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Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res. 1995 Aug 01; 55(15):3233-6.
Score: 0.030
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Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino Acids. 2014 Mar; 46(3):543-52.
Score: 0.026
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Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 2012 Feb; 42(2-3):529-38.
Score: 0.023
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Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 1989 Oct 17; 28(21):8446-53.
Score: 0.020
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Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochem J. 2009 Jul 29; 422(1):101-9.
Score: 0.020
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Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J Biol Chem. 2005 Dec 02; 280(48):39843-51.
Score: 0.015
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The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug; 384(8):1195-201.
Score: 0.013
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Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin Cancer Res. 2001 Feb; 7(2):391-9.
Score: 0.011
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Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998 Mar 06; 244(1):298-303.
Score: 0.009