"Polyamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Amine compounds that consist of carbon chains or rings containing two or more primary amino groups.
| Descriptor ID |
D011073
|
| MeSH Number(s) |
D02.092.782
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polyamines".
Below are MeSH descriptors whose meaning is more specific than "Polyamines".
This graph shows the total number of publications written about "Polyamines" by people in this website by year, and whether "Polyamines" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 0 | 3 |
| 1996 | 2 | 0 | 2 |
| 1997 | 3 | 0 | 3 |
| 1998 | 2 | 1 | 3 |
| 1999 | 2 | 0 | 2 |
| 2000 | 3 | 1 | 4 |
| 2001 | 3 | 1 | 4 |
| 2002 | 3 | 0 | 3 |
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 2 | 4 |
| 2007 | 2 | 0 | 2 |
| 2009 | 5 | 1 | 6 |
| 2010 | 1 | 0 | 1 |
| 2011 | 7 | 1 | 8 |
| 2013 | 2 | 1 | 3 |
| 2015 | 3 | 0 | 3 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polyamines" by people in Profiles.
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Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Med Sci (Basel). 2022 08 30; 10(3).
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Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade. J Immunother. 2021 10 01; 44(8):283-291.
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The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. Cancer Gene Ther. 2022 07; 29(7):940-950.
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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9.
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Polyamine catabolism and oxidative damage. J Biol Chem. 2018 11 30; 293(48):18736-18745.
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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677.
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Targeting polyamine metabolism for cancer therapy and prevention. Biochem J. 2016 10 01; 473(19):2937-53.
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A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. PLoS One. 2015; 10(5):e0127246.
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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorg Med Chem. 2015 Aug 15; 23(16):5131-43.
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Multifunctional drug nanocarriers formed by cRGD-conjugated ?CD-PAMAM-PEG for targeted cancer therapy. Colloids Surf B Biointerfaces. 2015 Feb 01; 126:590-597.