New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases.

New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases. J Med Chem. 2004 Jul 01; 47(14):3512-7.

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subject areas

Administration, Oral
AIDS-Related Opportunistic Infections
Animals
Anti-Bacterial Agents
Antifungal Agents
Anti-HIV Agents
Anti-Inflammatory Agents
Biological Availability
Carbazoles
Carbolines
Fourier Analysis
HIV-1
Indoles
Injections, Intravenous
Magnetic Resonance Spectroscopy
Male
Mass Spectrometry
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Porifera
Pyrroles
Quinolines
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

authors with profiles

Mark T. Hamann