Gustavo Leone to Animals
This is a "connection" page, showing publications Gustavo Leone has written about Animals.
Connection Strength
1.970
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The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nat Commun. 2023 01 03; 14(1):1.
Score: 0.062
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Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images. PLoS Comput Biol. 2022 03; 18(3):e1009949.
Score: 0.059
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Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma. Neoplasia. 2020 10; 22(10):484-496.
Score: 0.053
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The broken cycle: E2F dysfunction in?cancer. Nat Rev Cancer. 2019 06; 19(6):326-338.
Score: 0.048
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Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. Cell Rep. 2019 06 18; 27(12):3547-3560.e5.
Score: 0.048
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Endoreduplication of the mouse genome in the absence of ORC1. Genes Dev. 2018 07 01; 32(13-14):978-990.
Score: 0.045
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Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev Cell. 2017 05 22; 41(4):392-407.e6.
Score: 0.042
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annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq. Bioinformatics. 2017 May 15; 33(10):1570-1571.
Score: 0.042
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Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. J Clin Invest. 2017 Mar 01; 127(3):830-842.
Score: 0.041
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E2f8 mediates tumor suppression in postnatal liver development. J Clin Invest. 2016 08 01; 126(8):2955-69.
Score: 0.040
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Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice. Sci Data. 2016 Feb 16; 3:160008.
Score: 0.038
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The Spectrum of E2F in Liver Disease--Mediated Regulation in Biology and Cancer. J Cell Physiol. 2016 Jul; 231(7):1438-49.
Score: 0.038
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E2f3 in tumor macrophages promotes lung metastasis. Oncogene. 2016 07 14; 35(28):3636-46.
Score: 0.038
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Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes Dev. 2015 Aug 15; 29(16):1707-20.
Score: 0.037
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Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015 Aug; 17(8):1036-48.
Score: 0.037
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Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis. Oncogene. 2015 Jan 02; 34(1):119-28.
Score: 0.033
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Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov; 14(11):1192-202.
Score: 0.031
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Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17; 22(4):849-62.
Score: 0.029
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Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 01; 351(1):35-45.
Score: 0.027
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E2f1-3 are critical for myeloid development. J Biol Chem. 2011 Feb 11; 286(6):4783-95.
Score: 0.027
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Allele-specific tumor spectrum in pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5142-7.
Score: 0.025
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E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009 Dec 17; 462(7275):930-4.
Score: 0.025
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Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009 Nov; 9(11):785-97.
Score: 0.025
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Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. 2009 Oct 22; 461(7267):1084-91.
Score: 0.025
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E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. Mol Cell Biol. 2009 Jan; 29(2):414-24.
Score: 0.023
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Mouse development with a single E2F activator. Nature. 2008 Aug 28; 454(7208):1137-41.
Score: 0.023
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Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res. 2008 Feb 01; 68(3):937-45.
Score: 0.022
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Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15400-5.
Score: 0.021
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Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. Genesis. 2007 Mar; 45(3):129-34.
Score: 0.021
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E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol. 2007 Jan; 27(1):65-78.
Score: 0.020
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Rb is critical in a mammalian tissue stem cell population. Genes Dev. 2007 Jan 01; 21(1):85-97.
Score: 0.020
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Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. J Biol Chem. 2006 Nov 24; 281(47):36124-31.
Score: 0.020
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Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2005 May 06; 280(18):18211-20.
Score: 0.018
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Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2003 Oct 24; 278(43):42041-9.
Score: 0.016
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Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6546-51.
Score: 0.016
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Inactivation of E2F3 results in centrosome amplification. Cancer Cell. 2003 Apr; 3(4):333-46.
Score: 0.016
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Extra-embryonic function of Rb is essential for embryonic development and viability. Nature. 2003 Feb 27; 421(6926):942-7.
Score: 0.016
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Discovery of nonautonomous modulators of activated Ras. G3 (Bethesda). 2022 09 30; 12(10).
Score: 0.015
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Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. Mol Cancer Res. 2022 08 05; 20(8):1233-1246.
Score: 0.015
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STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. Life Sci Alliance. 2022 11; 5(11).
Score: 0.015
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Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human. Mol Cell Proteomics. 2022 05; 21(5):100225.
Score: 0.015
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Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. Oncogene. 2022 04; 41(15):2187-2195.
Score: 0.015
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The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22; 414(6862):457-62.
Score: 0.014
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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2021 11 02; 37(5):109934.
Score: 0.014
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Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circ Res. 2021 09 17; 129(7):735-750.
Score: 0.014
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Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. J Clin Invest. 2021 08 16; 131(16).
Score: 0.014
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Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul; 8(1):105-13.
Score: 0.014
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Stromal Platelet-Derived Growth Factor Receptor-? Signaling Promotes Breast Cancer Metastasis in the Brain. Cancer Res. 2021 02 01; 81(3):606-618.
Score: 0.013
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Cyclin D-CDK4/6 functions in cancer. Adv Cancer Res. 2020; 148:147-169.
Score: 0.013
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Modeling Human Cancer-induced Cachexia. Cell Rep. 2019 08 06; 28(6):1612-1622.e4.
Score: 0.012
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Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer. Breast Cancer Res. 2019 07 17; 21(1):80.
Score: 0.012
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Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression. Cancer Res. 2019 08 15; 79(16):4124-4134.
Score: 0.012
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Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6626-31.
Score: 0.012
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Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E109-E120.
Score: 0.012
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Periostin/?1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization. Biochim Biophys Acta Gen Subj. 2019 05; 1863(5):813-829.
Score: 0.012
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Stromal PTEN determines mammary epithelial response to radiotherapy. Nat Commun. 2018 07 17; 9(1):2783.
Score: 0.011
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Crosstalk between PKCa and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep. 2018 07 17; 24(3):655-669.
Score: 0.011
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Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. Oncogene. 2018 08; 37(32):4428-4442.
Score: 0.011
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hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood. 2018 04 05; 131(14):1532-1544.
Score: 0.011
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Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. J Clin Invest. 2018 01 02; 128(1):402-414.
Score: 0.011
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Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. PLoS One. 2017; 12(9):e0184984.
Score: 0.011
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NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809.
Score: 0.011
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Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression. Cancer Res. 2017 07 15; 77(14):3846-3856.
Score: 0.011
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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997 May 22; 387(6631):422-6.
Score: 0.010
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Stromal PDGFR-a Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth. Neoplasia. 2017 Jun; 19(6):496-508.
Score: 0.010
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Functional analysis of E2F transcription factor. Methods Enzymol. 1997; 283:205-19.
Score: 0.010
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Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. Oncogene. 2017 04 20; 36(16):2297-2308.
Score: 0.010
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Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 2016 09 01; 30(17):1943-55.
Score: 0.010
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Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia. Neoplasia. 2016 09; 18(9):541-52.
Score: 0.010
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RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. J Clin Invest. 2016 10 03; 126(10):3739-3757.
Score: 0.010
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Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene. 2017 02 09; 36(6):829-839.
Score: 0.010
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C-terminal trimerization, but not N-terminal trimerization, of the reovirus cell attachment protein Is a posttranslational and Hsp70/ATP-dependent process. J Biol Chem. 1996 Apr 05; 271(14):8466-71.
Score: 0.010
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FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol. 2016 Feb 15; 410(2):150-163.
Score: 0.010
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Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ. 2016 Apr; 23(4):565-75.
Score: 0.009
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PTEN is a negative regulator of NK cell cytolytic function. J Immunol. 2015 Feb 15; 194(4):1832-40.
Score: 0.009
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CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene. 2015 Jul; 34(28):3651-61.
Score: 0.009
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Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. Mol Cancer Res. 2014 Oct; 12(10):1355-64.
Score: 0.009
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Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014 Aug 01; 392(1):62-79.
Score: 0.008
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A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol. 2014 Jun; 34(11):2029-45.
Score: 0.008
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HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15; 74(8):2316-27.
Score: 0.008
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Reovirus protein sigma 1: from cell attachment to protein oligomerization and folding mechanisms. Bioessays. 1994 Mar; 16(3):199-206.
Score: 0.008
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Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol. 2014 Apr; 34(7):1363-77.
Score: 0.008
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Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. PLoS One. 2013; 8(8):e71533.
Score: 0.008
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A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013; 11(4):e1001536.
Score: 0.008
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Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell Stem Cell. 2013 Apr 04; 12(4):440-52.
Score: 0.008
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E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J. 2012 Oct 03; 31(19):3871-84.
Score: 0.008
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Loss of fibroblast HIF-1a accelerates tumorigenesis. Cancer Res. 2012 Jul 01; 72(13):3187-95.
Score: 0.007
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Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011 Dec 18; 14(2):159-67.
Score: 0.007
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S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Res. 2012 Feb 01; 72(3):604-15.
Score: 0.007
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The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. PLoS One. 2011; 6(10):e26019.
Score: 0.007
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Trimerization of the reovirus cell attachment protein (sigma 1) induces conformational changes in sigma 1 necessary for its cell-binding function. Virology. 1991 Oct; 184(2):758-61.
Score: 0.007
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The incorporation of reovirus cell attachment protein sigma 1 into virions requires the N-terminal hydrophobic tail and the adjacent heptad repeat region. Virology. 1991 May; 182(1):346-50.
Score: 0.007
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Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution. Cancer Res. 2011 Feb 15; 71(4):1203-7.
Score: 0.007
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Identifying nuclear phenotypes using semi-supervised metric learning. Inf Process Med Imaging. 2011; 22:398-410.
Score: 0.007
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Non-parametric population analysis of cellular phenotypes. Med Image Comput Comput Assist Interv. 2011; 14(Pt 2):343-51.
Score: 0.007
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The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene. 2010 Sep 09; 29(36):5103-12.
Score: 0.007
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An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res. 2010 Feb 15; 70(4):1323-33.
Score: 0.006
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Division and apoptosis of E2f-deficient retinal progenitors. Nature. 2009 Dec 17; 462(7275):925-9.
Score: 0.006
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Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One. 2009 Dec 14; 4(12):e8283.
Score: 0.006
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E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010 Jan; 30(2):524-36.
Score: 0.006
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Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther. 2009 Nov; 8(11):3117-29.
Score: 0.006
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Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood. 2009 Jul 30; 114(5):1123-30.
Score: 0.006
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Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 2009 Mar; 19(3):111-8.
Score: 0.006
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Tensor classification of N-point correlation function features for histology tissue segmentation. Med Image Anal. 2009 Feb; 13(1):156-66.
Score: 0.006
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Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. Cancer Res. 2008 Apr 15; 68(8):2671-7.
Score: 0.006
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An imaging workflow for characterizing phenotypical change in large histological mouse model datasets. J Biomed Inform. 2008 Dec; 41(6):863-73.
Score: 0.006
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Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008 Jan; 14(1):62-75.
Score: 0.005
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Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood. 2008 Jan 15; 111(2):816-28.
Score: 0.005
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Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J Virol. 2007 Dec; 81(23):13191-9.
Score: 0.005
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Detection and visualization of surface-pockets to enable phenotyping studies. IEEE Trans Med Imaging. 2007 Sep; 26(9):1283-90.
Score: 0.005
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CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet. 2007 Sep; 3(9):1757-69.
Score: 0.005
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Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol. 2007 Jul; 5(7):e179.
Score: 0.005
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Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol. 2007 Jul; 27(13):4825-43.
Score: 0.005
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Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest. 2006 Oct; 116(10):2707-16.
Score: 0.005
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E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene. 2005 Jul 21; 24(31):5000-4.
Score: 0.005
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Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature. 2004 Dec 23; 432(7020):1040-5.
Score: 0.004
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A NotI-EcoRV promoter library for studies of genetic and epigenetic alterations in mouse models of human malignancies. Genomics. 2004 Oct; 84(4):647-60.
Score: 0.004
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Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004 Sep 24; 279(39):40511-20.
Score: 0.004
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Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet. 2004 Apr; 36(4):351-60.
Score: 0.004
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Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice. Dev Neurosci. 2004; 26(5-6):435-45.
Score: 0.004
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Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells. Oncogene. 2003 Nov 20; 22(52):8472-86.
Score: 0.004
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Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-II. Mol Cell Endocrinol. 2003 Jan 31; 199(1-2):119-28.
Score: 0.004
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Structural characterization of Rasgrf1 and a novel linked imprinted locus. Gene. 2002 May 29; 291(1-2):287-97.
Score: 0.004
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Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1347-52.
Score: 0.004
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DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2. J Biol Chem. 2002 Mar 08; 277(10):8372-81.
Score: 0.004
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BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13901-6.
Score: 0.004
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Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. J Biol Chem. 2001 Aug 31; 276(35):32822-7.
Score: 0.003
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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol. 2001 Jul; 21(14):4684-99.
Score: 0.003
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Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ. 2000 Dec; 11(12):625-33.
Score: 0.003
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Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-beta1 is a cell cycle-independent effect and influences their hematopoietic potential. Blood. 2000 May 15; 95(10):3001-9.
Score: 0.003
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Ras enhances Myc protein stability. Mol Cell. 1999 Feb; 3(2):169-79.
Score: 0.003
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Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ. 1998 Apr; 9(4):297-303.
Score: 0.003
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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8.
Score: 0.003
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E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 1998 Feb; 9(2):113-8.
Score: 0.003
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Role of the Rb/E2F pathway in cell growth control. J Cell Physiol. 1997 Nov; 173(2):233-6.
Score: 0.003
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Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7245-50.
Score: 0.003
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The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol. 1996 Dec; 16(12):6965-76.
Score: 0.003
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Co-translational trimerization of the reovirus cell attachment protein. EMBO J. 1996 Jun 03; 15(11):2651-8.
Score: 0.002
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Binding of reovirus to receptor leads to conformational changes in viral capsid proteins that are reversible upon virus detachment. J Biol Chem. 1994 Jun 24; 269(25):17043-7.
Score: 0.002
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[The relationship between immunological defence and the development of tumours]. Arch Sci Med (Torino). 1973 Oct-Dec; 130(4):273-82.
Score: 0.002
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The N-terminal quarter of reovirus cell attachment protein sigma 1 possesses intrinsic virion-anchoring function. Virology. 1990 Nov; 179(1):95-103.
Score: 0.002