Gustavo Leone

TitleEndowed Chair, Grace E. DeWolff for Medical Oncology
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 955
HO124J
Hollings Cancer Center - 86 Jonathan Lucas St.
Phone843-792-1164
Fax843-792-3041
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P. RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2023 Mar 07; 42(3):112228. PMID: 36884347.
      Citations:    Fields:    
    2. Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G. The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nat Commun. 2023 01 03; 14(1):1. PMID: 36596776; PMCID: PMC9810714.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Fong BC, Chakroun I, Iqbal MA, Paul S, Bastasic J, O'Neil D, Yakubovich E, Bejjani AT, Ahmadi N, Carter A, Clark A, Leone G, Park DS, Ghanem N, Vandenbosch R, Slack RS. The Rb/E2F axis is a key regulator of the molecular signatures instructing the quiescent and activated adult neural stem cell state. Cell Rep. 2022 11 01; 41(5):111578. PMID: 36323247.
      Citations:    Fields:    Translation:Cells
    4. Corchado-Sonera M, Rambani K, Navarro K, Kladney R, Dowdle J, Leone G, Chamberlin HM. Discovery of nonautonomous modulators of activated Ras. G3 (Bethesda). 2022 09 30; 12(10). PMID: 35929788; PMCID: PMC9526067.
      Citations:    Fields:    Translation:AnimalsCells
    5. Wu J, Liu X, Reeser JAW, Trimboli AJ, Pécot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC, Wu J, Liu X, Reeser JAW, Trimboli AJ, P?cot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC. Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. Mol Cancer Res. 2022 08 05; 20(8):1233-1246. PMID: 35533313; PMCID: PMC9357052.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC, Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC. STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. Life Sci Alliance. 2022 11; 5(11). PMID: 35803738; PMCID: PMC9270499.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Han L, Seward C, Leone G, Ostrowski MC, Han L, Seward C, Leone G, Ostrowski MC. Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers. Adv Cancer Res. 2022; 154:169-201. PMID: 35459469.
      Citations:    Fields:    Translation:HumansCells
    8. Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC, Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC. Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human. Mol Cell Proteomics. 2022 05; 21(5):100225. PMID: 35331917; PMCID: PMC9092512.
      Citations:    
    9. Pécot T, Cuitiño MC, Johnson RH, Timmers C, Leone G, P?cot T, Cuiti?o MC, Johnson RH, Timmers C, Leone G. Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images. PLoS Comput Biol. 2022 03; 18(3):e1009949. PMID: 35286300; PMCID: PMC8947602.
      Citations:    
    10. Yoshida A, Phillips-Mason P, Tarallo V, Avril S, Koivisto C, Leone G, Diehl JA, Yoshida A, Phillips-Mason P, Tarallo V, Avril S, Koivisto C, Leone G, Diehl JA. Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. Oncogene. 2022 04; 41(15):2187-2195. PMID: 35210557.
      Citations:    
    11. George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P, George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P. RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2021 11 02; 37(5):109934. PMID: 34731628; PMCID: PMC8675433.
      Citations:    
    12. Chu H, Sacharidou A, Nguyen A, Li C, Chambliss KL, Salmon JE, Shen YM, Lo J, Leone GW, Herz J, Hui DY, Marciano DK, Abrahams VM, Natale BV, Montalbano AP, Xiao X, Xu L, Natale DR, Shaul PW, Mineo C, Chu H, Sacharidou A, Nguyen A, Li C, Chambliss KL, Salmon JE, Shen YM, Lo J, Leone GW, Herz J, Hui DY, Marciano DK, Abrahams VM, Natale BV, Montalbano AP, Xiao X, Xu L, Natale DR, Shaul PW, Mineo C. Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circ Res. 2021 09 17; 129(7):735-750. PMID: 34404233; PMCID: PMC8448973.
      Citations:    
    13. Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H, Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H. Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. J Clin Invest. 2021 08 16; 131(16). PMID: 34255748; PMCID: PMC8363288.
      Citations:    
    14. Koivisto CS, Parrish M, Bonala SB, Ngoi S, Torres A, Gallagher J, Sanchez-Hodge R, Zeinner V, Nahhas GJ, Liu B, Cohn DE, Backes FJ, Goodfellow PJ, Chamberlin HM, Leone G, Koivisto CS, Parrish M, Bonala SB, Ngoi S, Torres A, Gallagher J, Sanchez-Hodge R, Zeinner V, Nahhas GJ, Liu B, Cohn DE, Backes FJ, Goodfellow PJ, Chamberlin HM, Leone G. Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma. Neoplasia. 2020 10; 22(10):484-496. PMID: 32818842; PMCID: PMC7452078.
      Citations:    
    15. Thies KA, Hammer AM, Hildreth BE, Steck SA, Spehar JM, Kladney RD, Geisler JA, Das M, Russell LO, Bey JF, Bolyard CM, Pilarski R, Trimboli AJ, Cuitiño MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout JP, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM, Thies KA, Hammer AM, Hildreth BE, Steck SA, Spehar JM, Kladney RD, Geisler JA, Das M, Russell LO, Bey JF, Bolyard CM, Pilarski R, Trimboli AJ, Cuiti?o MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout JP, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM. Stromal Platelet-Derived Growth Factor Receptor-? Signaling Promotes Breast Cancer Metastasis in the Brain. Cancer Res. 2021 02 01; 81(3):606-618. PMID: 32327406; PMCID: PMC7581545.
      Citations:    
    16. Gao X, Leone GW, Wang H, Gao X, Leone GW, Wang H. Cyclin D-CDK4/6 functions in cancer. Adv Cancer Res. 2020; 148:147-169. PMID: 32723562.
      Citations:    
    17. Thies KA, Lefler JE, Leone G, Ostrowski MC, Thies KA, Lefler JE, Leone G, Ostrowski MC. PTEN in the Stroma. Cold Spring Harb Perspect Med. 2019 10 01; 9(10). PMID: 31427286; PMCID: PMC6771362.
      Citations:    
    18. Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC, Talbert EE, Cuiti?o MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC. Modeling Human Cancer-induced Cachexia. Cell Rep. 2019 08 06; 28(6):1612-1622.e4. PMID: 31390573; PMCID: PMC6733019.
      Citations:    
    19. Basree MM, Shinde N, Koivisto C, Cuitino M, Kladney R, Zhang J, Stephens J, Palettas M, Zhang A, Kim HK, Acero-Bedoya S, Trimboli A, Stover DG, Ludwig T, Ganju R, Weng D, Shields P, Freudenheim J, Leone GW, Sizemore GM, Majumder S, Ramaswamy B, Basree MM, Shinde N, Koivisto C, Cuitino M, Kladney R, Zhang J, Stephens J, Palettas M, Zhang A, Kim HK, Acero-Bedoya S, Trimboli A, Stover DG, Ludwig T, Ganju R, Weng D, Shields P, Freudenheim J, Leone GW, Sizemore GM, Majumder S, Ramaswamy B. Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer. Breast Cancer Res. 2019 07 17; 21(1):80. PMID: 31315645; PMCID: PMC6637535.
      Citations:    
    20. Orr RK, Hoehn JL, Col NF, Bowen C, Ostrowski MC, Leone G, Gelmann EP. Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression. Cancer Res. 2019 08 15; 79(16):4124-4134. PMID: 31213464; PMCID: PMC6753942.
      Citations:    
    21. Kent LN, Leone G, Kent LN, Leone G. The broken cycle: E2F dysfunction in?cancer. Nat Rev Cancer. 2019 06; 19(6):326-338. PMID: 31053804.
      Citations:    
    22. Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M, Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. Mol Cell. 2019 06 20; 74(6):1264-1277.e7. PMID: 31130363; PMCID: PMC6588466.
      Citations:    
    23. Cuitiño MC, Pécot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G, Cuiti?o MC, P?cot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G. Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. Cell Rep. 2019 06 18; 27(12):3547-3560.e5. PMID: 31130414; PMCID: PMC6673649.
      Citations:    
    24. Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME, Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E109-E120. PMID: 30990748.
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    25. Ghatak S, Misra S, Moreno-Rodrigue RA, Hascall VC, Leone GW, Markwald RR, Ghatak S, Misra S, Moreno-Rodrigue RA, Hascall VC, Leone GW, Markwald RR. Periostin/?1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization. Biochim Biophys Acta Gen Subj. 2019 05; 1863(5):813-829. PMID: 30742951.
      Citations:    
    26. Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC, Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE, Wang DJ, Steck SA, Donohue S, Cuiti?o MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC. Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth. Life Sci Alliance. 2018 Oct; 1(5):e201800190. PMID: 30456390; PMCID: PMC6238420.
      Citations:    
    27. Tang X, Srivastava A, Liu H, Machiraju R, Huang K, Leone G, Tang X, Srivastava A, Liu H, Machiraju R, Huang K, Leone G. annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq. Bioinformatics. 2018 08 15; 34(16):2879. PMID: 29672705; PMCID: PMC6084593.
      Citations:    
    28. Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD, Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD. Crosstalk between PKCa and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep. 2018 07 17; 24(3):655-669. PMID: 30021163; PMCID: PMC6118133.
      Citations:    
    29. Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC, Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuiti?o MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC. Stromal PTEN determines mammary epithelial response to radiotherapy. Nat Commun. 2018 07 17; 9(1):2783. PMID: 30018330; PMCID: PMC6050339.
      Citations:    
    30. Okano-Uchida T, Kent LN, Ouseph MM, McCarty B, Frank JJ, Kladney R, Cuitino MC, Thompson JC, Coppola V, Asano M, Leone G, Okano-Uchida T, Kent LN, Ouseph MM, McCarty B, Frank JJ, Kladney R, Cuitino MC, Thompson JC, Coppola V, Asano M, Leone G. Endoreduplication of the mouse genome in the absence of ORC1. Genes Dev. 2018 07 01; 32(13-14):978-990. PMID: 29967292; PMCID: PMC6075035.
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    31. Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK, Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuiti?o MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK. Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. Oncogene. 2018 08; 37(32):4428-4442. PMID: 29720724; PMCID: PMC7063845.
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    32. Rudolph M, Sizemore ST, Lu Y, Teng KY, Basree MM, Reinbolt R, Timmers CD, Leone G, Ostrowski MC, Majumder S, Ramaswamy B, Rudolph M, Sizemore ST, Lu Y, Teng KY, Basree MM, Reinbolt R, Timmers CD, Leone G, Ostrowski MC, Majumder S, Ramaswamy B. A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer. Breast Cancer Res Treat. 2018 Jun; 169(3):457-467. PMID: 29464534.
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    33. Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL, Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL. hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood. 2018 04 05; 131(14):1532-1544. PMID: 29437554; PMCID: PMC6027092.
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    34. Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP, Ollila S, Dom?nech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemel? EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, M?kel? TP. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. J Clin Invest. 2018 01 02; 128(1):402-414. PMID: 29202476; PMCID: PMC5749537.
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    35. Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC, Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC. Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. Oncogene. 2017 11 23; 36(47):6658. PMID: 29035387.
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    36. Wu J, Liu X, Nayak SG, Pitarresi JR, Cuitiño MC, Yu L, Hildreth BE, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC, Wu J, Liu X, Nayak SG, Pitarresi JR, Cuiti?o MC, Yu L, Hildreth BE, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC. Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. PLoS One. 2017; 12(9):e0184984. PMID: 28934293; PMCID: PMC5608307.
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    37. Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC, Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC. NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809. PMID: 28891811; PMCID: PMC5617672.
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    38. Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J, Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J. IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-?B. J Immunol. 2017 10 01; 199(7):2333-2342. PMID: 28842466; PMCID: PMC5624342.
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    39. Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio DA, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, Kladney RD, Leone G, Lev D, Croce CM, Pollock RE, Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio DA, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, Kladney RD, Leone G, Lev D, Croce CM, Pollock RE. Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression. Cancer Res. 2017 07 15; 77(14):3846-3856. PMID: 28588009; PMCID: PMC6033276.
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    40. Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G, Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev Cell. 2017 05 22; 41(4):392-407.e6. PMID: 28535374; PMCID: PMC5508591.
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    41. Orr RK, Hoehn JL, Col NF, Tang X, Srivastava A, Liu H, Machiraju R, Huang K, Leone G. annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq. Bioinformatics. 2017 May 15; 33(10):1570-1571. PMID: 28169395; PMCID: PMC5860050.
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    42. Hammer AM, Sizemore GM, Shukla VC, Avendano A, Sizemore ST, Chang JJ, Kladney RD, Cuitiño MC, Thies KA, Verfurth Q, Chakravarti A, Yee LD, Leone G, Song JW, Ghadiali SN, Ostrowski MC, Hammer AM, Sizemore GM, Shukla VC, Avendano A, Sizemore ST, Chang JJ, Kladney RD, Cuiti?o MC, Thies KA, Verfurth Q, Chakravarti A, Yee LD, Leone G, Song JW, Ghadiali SN, Ostrowski MC. Stromal PDGFR-a Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth. Neoplasia. 2017 Jun; 19(6):496-508. PMID: 28501760; PMCID: PMC5440288.
      Citations:    
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    137. Tanner SM, Austin JL, Leone G, Rush LJ, Plass C, Heinonen K, Mrózek K, Sill H, Knuutila S, Kolitz JE, Archer KJ, Caligiuri MA, Bloomfield CD, de La Chapelle A, Tanner SM, Austin JL, Leone G, Rush LJ, Plass C, Heinonen K, Mr?zek K, Sill H, Knuutila S, Kolitz JE, Archer KJ, Caligiuri MA, Bloomfield CD, de La Chapelle A. BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13901-6. PMID: 11707601; PMCID: PMC61139.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    138. Teofili L, Martini M, Di Mario A, Rutella S, Urbano R, Luongo M, Leone G, Larocca LM, Teofili L, Martini M, Di Mario A, Rutella S, Urbano R, Luongo M, Leone G, Larocca LM. Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. Blood. 2001 Jul 15; 98(2):495-7. PMID: 11435325.
      Citations: 6     Fields:    Translation:HumansCells
    139. Zhao YG, Gilmore R, Leone G, Coffey MC, Weber B, Lee PW, Zhao YG, Gilmore R, Leone G, Coffey MC, Weber B, Lee PW. Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. J Biol Chem. 2001 Aug 31; 276(35):32822-7. PMID: 11438552.
      Citations: 41     Fields:    Translation:AnimalsCells
    140. Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR, Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol. 2001 Jul; 21(14):4684-99. PMID: 11416145; PMCID: PMC87143.
      Citations: 237     Fields:    Translation:AnimalsCells
    141. Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR, Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul; 8(1):105-13. PMID: 11511364.
      Citations:    
    142. Rutella S, Pierelli L, Rumi C, Bonanno G, Marone M, Sica S, Capoluongo E, Ameglio F, Scambia G, Leone G, Rutella S, Pierelli L, Rumi C, Bonanno G, Marone M, Sica S, Capoluongo E, Ameglio F, Scambia G, Leone G. T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors. Exp Hematol. 2001 Apr; 29(4):401-15. PMID: 11301180.
      Citations: 2     Fields:    Translation:HumansCells
    143. Teofili L, Di Febo AL, Pierconti F, Maggiano N, Bendandi M, Rutella S, Cingolani A, Di Renzo N, Musto P, Pileri S, Leone G, Larocca LM, Teofili L, Di Febo AL, Pierconti F, Maggiano N, Bendandi M, Rutella S, Cingolani A, Di Renzo N, Musto P, Pileri S, Leone G, Larocca LM. Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease. Blood. 2001 Feb 15; 97(4):1063-9. PMID: 11159538.
      Citations: 25     Fields:    Translation:HumansCells
    144. Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C, Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C. Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum Mol Genet. 2001 Feb 01; 10(3):251-8. PMID: 11159944.
      Citations: 31     Fields:    Translation:HumansCells
    145. Orr RK, Hoehn JL, Col NF, Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ. 2000 Dec; 11(12):625-33. PMID: 11149597.
      Citations: 15     Fields:    Translation:AnimalsCells
    146. Marone M, Pierelli L, Mozzetti S, Masciullo V, Bonanno G, Morosetti R, Rutella S, Battaglia A, Rumi C, Mancuso S, Leone G, Giordano A, Scambia G, Marone M, Pierelli L, Mozzetti S, Masciullo V, Bonanno G, Morosetti R, Rutella S, Battaglia A, Rumi C, Mancuso S, Leone G, Giordano A, Scambia G. High cyclin-dependent kinase inhibitors in Bcl-2 and Bcl-xL-expressing CD34+-proliferating haematopoietic progenitors. Br J Haematol. 2000 Sep; 110(3):654-62. PMID: 10997978.
      Citations: 2     Fields:    Translation:HumansCells
    147. Pierelli L, Marone M, Bonanno G, Mozzetti S, Rutella S, Morosetti R, Rumi C, Mancuso S, Leone G, Scambia G, Pierelli L, Marone M, Bonanno G, Mozzetti S, Rutella S, Morosetti R, Rumi C, Mancuso S, Leone G, Scambia G. Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-beta1 is a cell cycle-independent effect and influences their hematopoietic potential. Blood. 2000 May 15; 95(10):3001-9. PMID: 10807762.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    148. Teofili L, Morosetti R, Martini M, Urbano R, Putzulu R, Rutella S, Pierelli L, Leone G, Larocca LM, Teofili L, Morosetti R, Martini M, Urbano R, Putzulu R, Rutella S, Pierelli L, Leone G, Larocca LM. Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation. Exp Hematol. 2000 May; 28(5):519-26. PMID: 10812241.
      Citations: 5     Fields:    Translation:HumansCells
    149. Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR, Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol. 2000 May; 20(10):3626-32. PMID: 10779352; PMCID: PMC85655.
      Citations: 85     Fields:    Translation:Cells
    150. Adams MR, Sears R, Nuckolls F, Leone G, Nevins JR, Adams MR, Sears R, Nuckolls F, Leone G, Nevins JR. Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol Cell Biol. 2000 May; 20(10):3633-9. PMID: 10779353; PMCID: PMC85656.
      Citations: 56     Fields:    Translation:Cells
    151. Leone G, DeGregori J, Jakoi L, Cook JG, Nevins JR, Leone G, DeGregori J, Jakoi L, Cook JG, Nevins JR. Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6626-31. PMID: 10359762; PMCID: PMC21965.
      Citations: 31     Fields:    Translation:AnimalsCells
    152. Sears R, Leone G, DeGregori J, Nevins JR, Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell. 1999 Feb; 3(2):169-79. PMID: 10078200.
      Citations: 178     Fields:    Translation:AnimalsCells
    153. Teofili L, Larocca LM, Leone G, Teofili L, Larocca LM, Leone G. Expression of p15(INK4B) in hematopoietic progenitors. Haematologica. 1999; 84(E-letters):E01. PMID: 11084659.
      Citations:    Fields:    Translation:HumansCells
    154. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR, Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998 Jul 15; 12(14):2120-30. PMID: 9679057; PMCID: PMC317011.
      Citations: 141     Fields:    Translation:HumansCells
    155. Smith EJ, Leone G, Nevins JR, Smith EJ, Leone G, Nevins JR. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ. 1998 Apr; 9(4):297-303. PMID: 9563849.
      Citations: 25     Fields:    Translation:AnimalsCells
    156. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS, Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8. PMID: 9520412; PMCID: PMC19882.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    157. Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR, Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 1998 Feb; 9(2):113-8. PMID: 9486847.
      Citations: 57     Fields:    Translation:AnimalsCells
    158. Nevins JR, Leone G, DeGregori J, Jakoi L, Nevins JR, Leone G, DeGregori J, Jakoi L. Role of the Rb/E2F pathway in cell growth control. J Cell Physiol. 1997 Nov; 173(2):233-6. PMID: 9365528.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    159. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR, DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7245-50. PMID: 9207076; PMCID: PMC23805.
      Citations: 237     Fields:    Translation:AnimalsCells
    160. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR, Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997 May 22; 387(6631):422-6. PMID: 9163430.
      Citations: 134     Fields:    Translation:AnimalsCells
    161. Nevins JR, DeGregori J, Jakoi L, Leone G, Nevins JR, DeGregori J, Jakoi L, Leone G. Functional analysis of E2F transcription factor. Methods Enzymol. 1997; 283:205-19. PMID: 9251021.
      Citations: 23     Fields:    Translation:AnimalsCells
    162. Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR, Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol. 1996 Dec; 16(12):6965-76. PMID: 8943352; PMCID: PMC231700.
      Citations: 70     Fields:    Translation:AnimalsCells
    163. Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR, Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol. 1996 Dec; 16(12):6977-84. PMID: 8943353; PMCID: PMC231701.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    164. Gilmore R, Coffey MC, Leone G, McLure K, Lee PW, Gilmore R, Coffey MC, Leone G, McLure K, Lee PW. Co-translational trimerization of the reovirus cell attachment protein. EMBO J. 1996 Jun 03; 15(11):2651-8. PMID: 8654362; PMCID: PMC450200.
      Citations: 11     Fields:    Translation:AnimalsCells
    165. Leone G, Coffey MC, Gilmore R, Duncan R, Maybaum L, Lee PW, Leone G, Coffey MC, Gilmore R, Duncan R, Maybaum L, Lee PW. C-terminal trimerization, but not N-terminal trimerization, of the reovirus cell attachment protein Is a posttranslational and Hsp70/ATP-dependent process. J Biol Chem. 1996 Apr 05; 271(14):8466-71. PMID: 8626547.
      Citations: 11     Fields:    Translation:AnimalsCells
    166. DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR, DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 1995 Dec 01; 9(23):2873-87. PMID: 7498785.
      Citations: 48     Fields:    Translation:Cells
    167. De Stefano V, Teofili L, Sica S, Mastrangelo S, Di Mario A, Rutella S, Salutari P, Rumi C, d'Onofrio G, Leone G, De Stefano V, Teofili L, Sica S, Mastrangelo S, Di Mario A, Rutella S, Salutari P, Rumi C, d'Onofrio G, Leone G. Effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells from patients with acute promyelocytic leukemia. Blood. 1995 Nov 01; 86(9):3535-41. PMID: 7579461.
      Citations: 5     Fields:    Translation:HumansCells
    168. Fernandes J, Tang D, Leone G, Lee PW, Fernandes J, Tang D, Leone G, Lee PW. Binding of reovirus to receptor leads to conformational changes in viral capsid proteins that are reversible upon virus detachment. J Biol Chem. 1994 Jun 24; 269(25):17043-7. PMID: 8006009.
      Citations: 12     Fields:    Translation:AnimalsCells
    169. Lee PW, Leone G, Lee PW, Leone G. Reovirus protein sigma 1: from cell attachment to protein oligomerization and folding mechanisms. Bioessays. 1994 Mar; 16(3):199-206. PMID: 8166674.
      Citations:    Fields:    Translation:HumansAnimalsCells
    170. Leone G, Maybaum L, Lee PW, Leone G, Maybaum L, Lee PW. The reovirus cell attachment protein possesses two independently active trimerization domains: basis of dominant negative effects. Cell. 1992 Oct 30; 71(3):479-88. PMID: 1423608.
      Citations: 15     Fields:    Translation:Cells
    171. Leone G, Duncan R, Lee PW, Leone G, Duncan R, Lee PW. Trimerization of the reovirus cell attachment protein (sigma 1) induces conformational changes in sigma 1 necessary for its cell-binding function. Virology. 1991 Oct; 184(2):758-61. PMID: 1887593.
      Citations: 6     Fields:    Translation:AnimalsCells
    172. Strong JE, Leone G, Duncan R, Sharma RK, Lee PW, Strong JE, Leone G, Duncan R, Sharma RK, Lee PW. Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer. Virology. 1991 Sep; 184(1):23-32. PMID: 1871968; PMCID: PMC7130766.
      Citations: 27     Fields:    Translation:Cells
    173. Duncan R, Horne D, Strong JE, Leone G, Pon RT, Yeung MC, Lee PW, Duncan R, Horne D, Strong JE, Leone G, Pon RT, Yeung MC, Lee PW. Conformational and functional analysis of the C-terminal globular head of the reovirus cell attachment protein. Virology. 1991 Jun; 182(2):810-9. PMID: 2024499.
      Citations: 17     Fields:    Translation:Cells
    174. Leone G, Duncan R, Mah DC, Price A, Cashdollar LW, Lee PW, Leone G, Duncan R, Mah DC, Price A, Cashdollar LW, Lee PW. The N-terminal heptad repeat region of reovirus cell attachment protein sigma 1 is responsible for sigma 1 oligomer stability and possesses intrinsic oligomerization function. Virology. 1991 May; 182(1):336-45. PMID: 2024469; PMCID: PMC7130816.
      Citations: 12     Fields:    Translation:Cells
    175. Leone G, Mah DC, Lee PW, Leone G, Mah DC, Lee PW. The incorporation of reovirus cell attachment protein sigma 1 into virions requires the N-terminal hydrophobic tail and the adjacent heptad repeat region. Virology. 1991 May; 182(1):346-50. PMID: 2024470.
      Citations: 13     Fields:    Translation:AnimalsCells
    176. Mah DC, Leone G, Jankowski JM, Lee PW, Mah DC, Leone G, Jankowski JM, Lee PW. The N-terminal quarter of reovirus cell attachment protein sigma 1 possesses intrinsic virion-anchoring function. Virology. 1990 Nov; 179(1):95-103. PMID: 2219743.
      Citations: 17     Fields:    Translation:AnimalsCells
    177. Orr RK, Hoehn JL, Col NF, Leone G. [The relationship between immunological defence and the development of tumours]. Arch Sci Med (Torino). 1973 Oct-Dec; 130(4):273-82. PMID: 17343168.
      Citations:    
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