Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.

Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model. Cancer Immunol Immunother. 2008 Apr; 57(4):563-72.

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subject areas

Animals
Apoptosis
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Survival
Disease Models, Animal
Flow Cytometry
Immunotherapy, Adoptive
Interleukin-12
L-Selectin
Lymphocyte Activation
Melanoma, Experimental
Mice
Mice, Transgenic
T-Lymphocyte Subsets

authors with profiles

David J. Cole